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Table 1 Clinical features of respiratory infection in the children with XHIGM

From: Respiratory infections in X-linked hyper-IgM syndrome with CD40LG mutation: a case series of seven children in China

Patients

Age (months)

Gender

Respiratory symptoms and signs

Pathogens

Pulmonary imaging

Prognosis

1

13

M

Cough, fever, polypnea

T. marneffei (BALF,Airway mucosal biopsy)

Multiple patchy, Hilar lymphadenopathy

Survival

2

6

M

Cough, fever, polypnea

P. carinii, CMV(BALF)

Ground-glass opacity

Survival

3

4

M

Cough, fever, polypnea

HAdV(BALF, Nasopharyngeal swabs)

Ground-glass opacity

Died

4

5

M

Cough, polypnea

CMV(Sputum)

Ground-glass opacity

Survival

5

19

M

Cough, fever

T. marneffei(Blood)

Multiple nodules, Hilar and mediastinal lymphadenopathy

Survival

6

15

M

Cough, fever, wheeze, polypnea

T. marneffei(Blood)

Hydrothorax, Hilar and mediastinal lymphadenopathy

Survival

7

20

M

Cough, fever

T. marneffei(Airway mucosal biopsy)

Multiple nodules and patchy, Hilar lymphadenopathy

Survival

  1. T marneffei Talaromyces marneffei, P carinii Pneumocystis carinii, BALF Bronchoalveolar lavage fluid, HAdV Human adenovirus, CMV Cytomegalovirus