Fig. 2

CLOCC in an 11-year-old boy with MIS-C. Brain MRI shows a lesion in the splenium of the corpus callosum (arrows) which is hypersignal on T2W (a) and FLAIR (b) sequences and was hyposignal on pre-contrast T1W sequence (c). There is no abnormal enhancement after the administration of the contrast agent (d). There is also increased signal intensity on DWI sequences at b 1000 s/mm2 (e) associated with loss of signal on the apparent diffusion coefficient map (f). These findings represent a focus of cytotoxic edema in the splenium of the corpus callosum