Skip to main content

Table 3 Crude and adjusted odd ratios of factors associated with non-adherence to ART among HIV infected children aged 6 -17years old in urban health facilities of Dire D Dawa, 2020 (n = 272)

From: Antiretroviral therapy non-adherence among children living with HIV in Dire Dawa, Eastern Ethiopia: a case-control study

Variables

 

cOR, 95% CI

P-value

aOR, 95% CI

Model 1†

P-value

aOR, 95% CI

Model 2Â¥

P-value

Caregiver’s substance use

No

Ref.

 

Ref.

 

Ref.

 

Yes

2.92 (1.70, 5.02)

< 0.001

2. 47 (1.31, 4.66)

0.005

2.87 (1.44, 5.71)

0.003

Child age

6–9

Ref.

 

Ref.

 

Ref.

 

10–14 years

0.28 (0.13, 0.60)

0.001

0. 62 (0.25, 1.51)

0.290

0.34 (0.12, 0.99)

0.048

15–17 years

0.21 (0.10, 0.45)

< 0.001

1.44 (0.42, 4.91)

0.557

0.83 (0.21, 3.33)

0.789

HIV status disclosure

No

Ref.

 

Ref.

 

Ref.

 

Yes

0.22 (0.12, 0.38)

< 0.001

0.31 (0.14, 0.69)

0.004

0.30 (0.13, 0.72)

0.007

ART dose

Once daily

Ref.

< 0.001

Ref.

 

Ref.

 

12 hourly

(two doses)

2.66 (1.55, 4.58)

 

0.50 (0.19, 1.34)

0.168

0.41 (0.15, 1.14)

0.086

Monthly family income (in ETB)

<2500

Ref.

 

Ref.

 

Ref.

 
 

2500–4999

1.23 (0.71, 2.15)

0.464

1.43 (0.75, 2.72)

0.279

1.65 (0.82, 3.35)

0.164

 

≥ 5000

0.77 (0.27, 2.22)

0.633

0.73 (0.22, 2.38)

0.598

0.76 (0.22, 2.66)

0.669

Relation with child

Biological parent

Ref.

 

Ref.

 

Ref.

 
 

Non-biological parent

0.98 (0.48, 1.97)

0.945

1.52 (0.56, 4.11)

0.410

1.76 (0.59, 5.25)

0.314

Caregiver’s HIV status

Positive

Ref.

 

Ref.

 

Ref.

 

Negative

0.64 (0.26, 1.54)

0.315

0.55 (0.16, 1.85)

0.334

0.65 (0.17, 2.52)

0.531

ART regimen backbone

TDF + 3TC

Ref.

 

Ref.

 

Ref.

 

AZT + 3TC

5.44 (2.87, 10.30)

< 0.001

5.40 (1.95, 14.98)

0.001

4.12 (1.43, 11.86)

0.009

ABC + 3TC

4.31 (2.06, 9.01)

< 0.001

5.56 (1.85, 16.73)

0.002

5.58 (1.70, 18.30)

0.005

Viral load change against the first measurement

Remained ND

Ref.

 

***

***

Ref.

 

Decreased to or remained < 1000

3.47 (1.41, 8.51)

0.007

***

***

4.87 (1.65, 14.33)

0.004

Remained at > = 1000 or increased from ND

6.90 (3.18, 14.98)

< 0.001

***

***

9.30 (3.69, 23.46)

< 0.001

  1. aOR = adjusted odds ratio, cOR = Crude odds ratio, ART = Antiretroviral Therapy, HIV = Human Immunodeficiency, and Virus ND = Not Detectable. †as part of sensitivity analysis, model I was run without a variable called ‘viral load change’ in the model and ¥model II was run including it in the final model