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Table 5 Association of the PART1 rs27565 and DEFB1 rs11362 genotypes with caries

From: Associations of PART1 and DEFB1 polymorphisms with Dental Caries in twelve-year-old children in Southern China: a cross-sectional study

SNP

Model

Variable

Caries-free

n (%)

Caries experience

n (%)

 

Univariate analysis

  

Multivariate analysis

 
 

OR (95% CI)

P value

 

OR (95% CI)

P* value

PART1 rs27565

Codominant

TT

189 (32.3)

118 (24.8)

 

Ref

  

Ref

 
  

TC

282 (48.1)

227 (47.8)

 

1.289 (0.966–1.721)

0.085

 

1.198 (0.892–1.607)

0.230

  

CC

115 (19.6)

130 (27.4)

 

1.811 (1.288–2.545)

0.001

 

1.692 (1.194–2.397)

0.003

 

Dominant

TT

189 (32.3)

118 (24.8)

 

Ref

  

Ref

 
  

TC + CC

397 (67.7)

357 (75.2)

 

1.440 (1.099–1.888)

0.008

 

1.338 (1.015–1.764)

0.039

 

Additive

–

–

–

 

1.343 (1.133–1.592)

0.001

 

1.296 (1.089–1.543)

0.003

 

Allelic

T

660 (56.3)

463 (48.7)

 

Ref

  

Ref

 
  

C

512 (43.7)

487 (51.3)

 

1.356 (1.142–1.610)

0.001

 

1.303 (1.094–1.911)

0.003

DEFB1 rs11362

Codominant

CC

337 (57.5)

225 (47.4)

 

Ref

  

Ref

 
  

CT

208 (35.5)

196 (41.3)

 

1.411 (1.090–1.827)

0.009

 

1.300 (0.995–1.700)

0.055

  

TT

41 (7.0)

54 (11.4)

 

1.973 (1.271–3.062)

0.002

 

1.713 (1.084–2.708)

0.021

 

Dominant

CC

337 (57.5)

225 (47.4)

 

Ref

  

Ref

 
  

CT + TT

249 (42.5)

250 (52.6)

 

1.504 (1.179–1.918)

0.001

 

1.364 (1.056–1.762)

0.017

 

Additive

–

–

–

 

1.407 (1.167–1.696)

< 0.001

 

1.306 (1.072–1.590)

0.008

 

Allelic

C

882 (75.3)

646 (68.0)

 

Ref

  

Ref

 
  

T

290 (24.7)

304 (32.0)

 

1.431 (1.183–1.731)

< 0.001

 

1.307 (1.074–1.592)

0.008

  1. SNP: single-nucleotide polymorphism, OR: odds ratio, CI: confidence interval, *: Adjusted for sex, ethnicity and frequency of sugary food intake
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