Outcomes and predictors of functioning, mental health, and health-related quality of life in adults born with very low birth weight: a prospective longitudinal cohort study

Wollum, Arnt Erik Karlsen; Berdal, Elias Kjølseth; Iversen, Johanne Marie; Indredavik, Marit S.; Evensen, Kari Anne I.

doi:10.1186/s12887-022-03676-6

Table 3 Predictors of adult outcomes in very low birth weight participants

From: Outcomes and predictors of functioning, mental health, and health-related quality of life in adults born with very low birth weight: a prospective longitudinal cohort study

	ASR Mean Adaptive			GAF Function			GAF Symptom			HADS Total			SF-36 Mental			SF-36 Physical
	B	(95% CI)	p	B	(95% CI)	p	B	(95% CI)	p	B	(95% CI)	p	B	(95% CI)	p	B	(95% CI)	p
Maternal factors
Maternal glucocorticoids	0.1	(-2.8, 2.9)	0.969	3.7	(-5.8, 13.8)	0.447	0.8	(-8.3, 9.4)	0.856	-1.8	(-5.7, 2.2)	0.370	1.3	(-5.8, 8.2)	0.699	-0.4	(-5.2, 4.2)	0.859
Parental SES	-0.5	(-1.7,0.7)	0.421	-1.7	(-6.0, 2.7)	0.504	-1.7	(-5.7, 2.6)	0.471	0.9	(-0.3, 2.1)	0.138	-2.5	(-4.9, -0.4)	0.019	2.1	(0.4, 4.2)	0.023
Perinatal Factors
Birthweight (pr.100 g)	0.3	(-0.2, 0.8)	0.282	2.5	(-0.1, 4.5)	0.048	1.1	(-0.8, 3.0)	0.264	-1.0	(-1.7, -0.3)	0.011	1.0	(-0.8, 2.4)	0.237	-0.4	(-1.4, 0.6)	0.401
Gestational age (weeks)	0.5	(-0.01, 0.9)	0.058	0.6	(-1.7, 2.9)	0.577	0.6	(-1.5, 2.8)	0.534	-0.6	(-1.0, 0.1)	0.040	0.4	(-0.9, 1.4)	0.477	-0.4	(-1.2, 0.4)	0.335
Apgar at 5 min	0.1	(-0.8, 0.9)	0.853	1.3	(-1.7, 4.8)	0.425	0.7	(-2.3, 4.3)	0.679	-0.7	(-1.9, 0.3)	0.191	0.6	(-1.6, 2.6)	0.548	-0.6	(-1.9, 0.8)	0.344
Days with respiratory support	-0.1	(-0.2, -0.03)	0.102	-0.5	(-0.9, 0.01)	0.019	-0.5	(-0.9, 0.1)	0.020	0.2	(0.1, 0.6)	0.013	-0.3	(-0.7, -0.2)	0.024	0.1	(-0.1, 0.2)	0.233
Days in NICU	0.01	(-0.04, 0.02)	0.592	-0.1	(-0.3, 0.03)	0.513	-0.01	(-0.2, 0.04)	0.778	0.02	(-0.06, 0.1)	0.362	-0.01	(-0.2, 0.03)	0.870	-0.02	(-0.1, 0.1)	0.335
IVH	0.3	(-1.6, 5.5)	0.674	-6.8	(-11.6, 14.2)	0.066	-7.8	(-11.8, 13.3)	0.030	3.1	(-1.5, 7.9)	0.056	-4.8	(-15.5, 6.7)	0.119	2.0	(-5.7, 4.2)	0.276
BPD	-2.3	(-5.6, 1.0)	0.189	-10.0	(-22.4, 2.5)	0.128	-7.9	(-20.6, 4.6)	0.228	3.8	(-0.2, 7.9)	0.062	-2.6	(-10.0, 4.2)	0.501	0.6	(-4.4, 6.2)	0.823
Sepsis at birth	4.2	(-0.1, 8.2)	0.040	-0.5	(-31.4, 16.3)	0.969	8.3	(1.2, 14.7)	0.025	-2.1	(-5.7, 1.1)	0.202	7.1	(0.5, 13.5)	0.030	-2.2	(-9.1, 4.8)	0.472
Motor Function
BSID PDI 1y	0.03	(-0.1, 0.2)	0.787	-0.02	(-0.3, 0.5)	0.848	-0.1	(-0.3, 0.4)	0.590	-0.1	(-0.4, 0.04)	0.204	0.1	(-0.1, 0.5)	0.653	0.1	(-0.2, 0.3)	0.196
PDMS Eye-hand 5y	0.1	(-0.3, 0.6)	0.635	1.1	(-0.2, 2.5)	0.305	0.8	(-0.7, 2.2)	0.463	-0.4	(-0.8, 0.2)	0.122	0.3	(-0.6, 1.0)	0.608	0.6	(0.2, 1.1)	0.008
PDMS Balance 5y	0.4	(-0.6, 0.9)	0.450	0.8	(-2.0, 3.4)	0.659	0.5	(-2.3, 3.1)	0.794	-0.3	(-1.1, 1.2)	0.459	0.2	(-1.2, 1.1)	0.735	0.7	(-0.1, 1.2)	0.026
PDMS Locomotor 5y	0.1	(-0.2, 0.4)	0.558	0.5	(-0.4, 1.3)	0.390	0.3	(-0.6, 1.1)	0.627	-0.2	(-0.4, 0.3)	0.268	0.1	(-0.3, 0.5)	0.592	0.3	(-0.1, 0.5)	0.045
MABC Total 14y	-0.1	(-0.3, 0.3)	0.650	-0.7	(-1.5, 0.4)	0.080	-0.8	(-1.5, 0.4)	0.042	0.4	(0.1, 0.6)	0.003	-0.7	(-1.0, -0.1)	0.002	-0.2	(-0.5, 0.1)	0.212
Cerebral palsy	-2.6	(-16.7, 9.4)	0.686	-28.1	(-61.8, 13.4)	0.169	-12.1	(-38.6, 3.5)	0.291	2.0	(-7.5, 8.9)	0.658	1.3	(-10.8, 16.1)	0.846	-1.2	(-11.9, 15.5)	0.894
Cognitive Function
BSID MDI 1y	0.02	(-0.2, 0.3)	0.863	-0.04	(-0.3, 0.3)	0.679	-0.2	(-0.4, 0.1)	0.120	0.1	(-0.1, 0.4)	0.513	-0.2	(-0.7, 0.1)	0.213	0.1	(-0.2, 0.3)	0.372
WPPSI 5y	-0.02	(-0.2, 0.1)	0.800	0.01	(-0.5, 0.3)	0.971	-0.03	(-0.5, 0.2)	0.776	-0.02	(-0.1, 0.1)	0.773	-0.1	(-0.3, 0.2)	0.281	0.2	(0.1, 0.4)	0.007
WISC-III 14y	-0.03	(-0.1, 0.04)	0.411	0.4	(0.1, 0.7)	0.053	0.1	(-0.05, 0.4)	0.186	-0.1	(-0.1, 0.04)	0.198	0.1	(-0.1, 0.3)	0.499	0.1	(-0.02, 0.2)	0.057

ASR: Adult Self-Report, B: Unstandardised beta; BPD: Bronchopulmonary Dysplasia, BSID: Bayley Scales of Infant Development, IVH: Intraventricular Haemorrhage, MABC: Movement Assessment Battery for Children, MDI: Mental Development Index, PDI: Psychomotor Development Index, PDMS: Peabody Developmental Motor Scales, SES: Socioeconomic status, SF-36: Short Form 36 Health Survey, WISC-III: Wechsler Intelligence Scale for Children – Third edition, WPPSI-R: Wechsler Preschool and Primary Scale of Intelligence – Revised. Linear regression using ASR Mean Adaptive score, GAF Function and Symptom scores, HADS Total score and SF-36 Physical and Mental Component Summaries as dependent variables, and maternal and perinatal factors as well as motor and cognitive function as independent variables. Confidence intervals and p-values are based on bias-corrected and accelerated bootstrap (BCa).

Back to article page

ISSN: 1471-2431

Contact us

Submission enquiries: bmcpediatrics@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Pediatrics

Contact us