Table 1 General characteristics of patients in the light and deep sedation groups

Age (years)

3.44 ± 2.90

4.25 ± 3.36

0.914

0.370

M/F (n)

7/7

14/7

0.972

0.324

Hospital stay (days)

14.14 ± 11.73

18.62 ± 10.41

-1.185

0.245

PELOD-2

4 (3–6)

5 (4–6)

0.048

0.275

Type I respiratory failure

2 (14.3%)

3 (14.3%)

0

1

Type II respiratory failure

12 (85.7%)

18 (85.7%)

ARDS

4 (28.6%)

7 (33.3%)

0.088

0.766

Sepsis

2 (14.3%)

5 (23.8%)

0.476

0.490

MODS

1 (4.8%)

2 (14.3%)

0.972

0.324

Lung imaging

3.889

0.274

Bilateral diffuse inflammation, partial consolidation

6 (42.9%)

12 (57.1%)

Lobar consolidation and atelectasis

4 (28.6%)

1 (4.8%)

Bilateral diffuse effusion

2 (14.3%)

4 (19.0%)

Bronchial stenosis and occlusion

2 (14.3%)

4 (19.0%)

Concomitant pleural effusion

4 (28.6%)

4 (19.0%)

0.432

0.398

Concomitant pneumothorax, subcutaneous emphysema

1 (7.1%)

4 (19.0%)

0.972

0.321

Duration of mechanical ventilation (h)

123.14 ± 96.52

193.38 ± 162.14

6.359

0.017

Midazolam (ug/kg.d-1)

5588.14 ± 1370.11

8756.14 ± 5022.65

-2.380

0.023

Duration of sedation (d)

5.12 ± 4.03

8.03 ± 6.77

-1.592

0.017

WBC (*10⁹/L)

13.5 ± 10.15

13.8 ± 11.05

-0.087

0.937

C-reactive protein (mg/L)

65.18 ± 66.49

49.45 ± 49.02

0.806

0.426

Procalcitonin (ng/mL)

6.14 ± 4.33

29.54 ± 23.49

-1.376

0.182

Blood lactate (mmol/L)

2.56 ± 1.18

2.78 ± 1.87

-0.385

0.703

PaO₂ (mmHg)

66.22 ± 16.81

66.14 ± 11.85

-1.910

0.850

PaCO₂ (mmHg)

66.28 ± 21.86

86.14 ± 28.31

-2.217

0.034

Etiology

  M. pneumoniae

6 (42.9%)

7 (33.3%)

0.326

0.413

  Adenovirus

2 (14.3%)

5 (23.8%)

0.476

0.406

  Type A/B influenza virus

3 (21.4%)

6 (28.6%)

0.224

0.474

  S. pneumoniae

1 (7.1%)

1 (4.8%)

0.088

0.647

  S. aureus

0 (0)

2 (9.5%)

1.414

0.353

  Cytomegalovirus

2 (14.3%)

2 (9.5%)

0.188

0.530

  Unknown etiology

6 (42.9%)

7 (33.3%)

0.326

0.413