Time to appropriate antimicrobial therapy serves an independent prognostic indicator in children with nosocomial Klebsiella pneumoniae bloodstream infection

Table 5 Logistic regression analysis of risk factors of septic shock among 67 nosocomial K. pneumoniae bloodstream infection children

Variables	Univariate analysis			Multivariate analysis
Variables	OR	95%CI	P	OR	95%CI	P
TTAT ≥ 10.7 h	8.79	2.08–37.11	0.003*	9.87	1.46–66.59	0.019*
PRISM III scores ≥ 10	5.78	1.00–33.24	0.049*	9.69	1.15–81.39	0.036*
TTP ≤ 13 h	5.02	1.35–18.67	0.016*	8.28	1.37–50.10	0.021*
Need for invasive mechanical ventilation	10.00	2.33–42.97	0.002*	6.52	1.08–39.51	0.042*
With secondary hypoalbuminemia during hospitalization	5.25	1.17–23.55	0.030*
Extended spectrum beta-lactamase bacteria	4.17	1.02–17.13	0.047*
Cephalosporin resistant bacteria	3.21	0.84–12.23	0.087

Abbreviations: PRISM pediatric risk of mortality, TTAT time to appropriate therapy, TTP time to positivity
^* indicates statistical significance, P < 0.05

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