Time to appropriate antimicrobial therapy serves an independent prognostic indicator in children with nosocomial Klebsiella pneumoniae bloodstream infection

Table 4 Logistic regression analysis of risk factors of in-hospital mortality among 67 K. pneumoniae bloodstream infection children

Variables	Univariate analysis			Multivariate analysis
Variables	OR	95%CI	P	OR	95%CI	P
PRISM III scores ≥ 10	9.17	1.50–55.93	0.016*	40.06	2.32–691.35	0.011*
TTP ≤ 13 h	6.92	1.52–31.56	0.012*	22.60	1.78–287.27	0.016*
TTAT ≥ 10.7 h	9.19	1.72–48.98	0.009*	22.19	1.25–393.94	0.035*
Need for invasive mechanical ventilation	10.83	2.27–51.71	0.003*	12.21	1.06–140.67	0.045*
Extended spectrum beta-lactamase bacteria	11.33	1.33–96.67	0.026*
Cephalosporin resistant bacteria	6.00	1.37–26.38	0.018*
With secondary hypoalbuminemia during hospitalization	3.73	1.03–13.59	0.046*

Abbreviations: PRISM pediatric risk of mortality, TTAT time to appropriate therapy, TTP time to positivity
^*Indicates statistical significance, P < 0.05

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