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Table 4 Uni- and multivariable logistic regression analysis of the perinatal-neonatal risks of NRF mortality

From: Outcome of neonatal hypoxemic respiratory failure: a livebirth population-based retrospective survey

 

Crude OR (95%CI)a

Adjusted OR (95%CI)b

BW < 1000 (g)

9.97 (3.68, 27.0)***

7.13 (1.70, 29.9)**

 1000–1499

1.84 (1.16, 2.93)*

7.21 (2.83, 18.4)***

 1500–2499

0.43 (0.26, 0.70)**

1.02 (0.45, 2.33)

 2500–3999

1.00 (reference)

1.00 (reference)

 ≥ 4000

0.85 (0.28, 2.59)

0.13 (0.02, 0.98)*

Born in level III hospitals

0.53 (0.37, 0.77)***

0.44 (0.24, 0.81)**

Cesarean delivery

0.38 (0.26, 0.55)***

0.30 (0.17, 0.55)***

Higher SNAPPE-II

2.43 (2.09, 2.82)***

2.29 (1.89, 2.78)***

Respiratory distress syndrome

1.44 (1.00, 2.07)

3.56 (1.05, 12.1)*

Meconium aspiration syndrome

3.92 (1.30, 11.9)*

31.5 (4.81, 206)***

Pneumonia/sepsis (primary)

0.38 (0.24, 0.59)***

2.72 (0.80, 9.26)

Congenital anomalies

4.50 (2.78, 7.31)***

30.0 (7.55, 119)***

Pulmonary hemorrhage

11.9 (5.34, 26.7)***

3.42 (1.05, 11.1)*

PPHN

6.74 (3.76, 11.1)***

3.42 (1.05, 11.1)*

Patent ductus arteriosus

2.30 (1.37, 3.89)**

0.42 (0.16, 1.08)

Necrotizing enterocolitis

4.19 (2.72, 7.72)***

7.96 (3.28, 19.4)***

CPAP

0.17 (0.11, 0.25)***

0.09 (0.04, 0.20)***

MV

3.04 (2.08, 4.44)***

0.43 (0.22, 0.84)*

  1. Abbreviations: NRF Neonatal respiratory failure, OR Odds ratio, CI Confidence interval, BW Birthweight, SNAPPE-II Score for neonatal acute physiology perinatal extension II, PPHN persistent pulmonary hypertension of the newborn, CPAP Continuous positive airway pressure, MV Mechanical ventilation
  2. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. reference
  3. aVariables listed in the table are selected by backward stepwise logistic regression model, with the crude OR analyzed by univariable model
  4. bAdjusted by all the variables listed in the table through multivariable logistic regression model (Hosmer-Lemeshow goodness of fit, P = 0.344)