Table 3 Final model of multivariate logistic regression of factors associated with osteopenia of prematurity

BLOCK 1: Maternal social and clinical variables

 Marital status

0.166

0.038^b

  Single

1

1

  Married

0.43 (0.17–1.06)

0.10 (0.02–0.59)

  Stable union

0.72 (0.25–2.09)

0.72 (0.11–4.79)

 Smoking

0.142

0.171

  Yes

1

1

  No

0.66 (0.49–0.90)

21.8 (0.27–17.88)

 Antepartum nutritional status

0.074

0.131

  Adequate

1

1

  Low weight

3.86 (0.94–15.7)

2.71 (0.30–24.5)

  Excess weight

2.57 (1.08–6.10)

6.72 (1.33–34.0)

 Comorbidities in pregnancy

  Urinary tract infection

1.21 (0.87–1.67)

0.165

0.56 (0.14–2.21)

0.411

BLOCK 2: Clinical variables of the preterm newborn

 Weight at birth

 < 0.001

0.028^b

   ≥ 1,000 g

1

1

   < 1,000 g

3,59 (2.21–5.84)

5.49 (1.20–25.1)

 APGAR 1^st minute

0.017

0.273

   ≥ 7

1

1

   < 7

1.76 (1.06–2.92)

2.22 (0.53–9.26)

 Ventilatory support

  Mechanical ventilation

1.05 (1.03–1.08)

 < 0.001

1.09 (1.03–1.18)

0.007^b

 Clinical diagnosis

  Sepsis

1.64 (1.19–2.25)

0.001

5.71 (1.35–24.2)

0.018^b

 Medications (Duration)

  Methylxanthines

1.09 (1.05–1.13)

 < 0.001

1.06 (0.99–1.13)

0.060

  Sedatives

1.02 (0.99–1.05)

0.143

0.89 (0.83–0.98)

0.010^b

BLOCK 3: Nutrition routes and bioavailability

 Acidity in the first week

0.025

0.035^b

   < 4 ºDornic

1

1

   ≥ 4 ºDornic

1.45(1.001–2.11)

5.36 (1.13–25.5)

BLOCK 4: Nutritional supply

 Calcium (mg/kg)

1.01 (1.00–1.02)

0.013

1.05 (1.006–1.1)

0.025^b

 Phosphorus (mg/kg)

1.02 (1.00–1.03)

0.008

0.95 (0.89–1.01)

0.091