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Table 2 Comparison of different correction formulas for the detection of bacterial and/or viral meningitis in neonates with traumatic LPs

From: Interpretation of white blood cell counts in the cerebrospinal fluid of neonates with traumatic lumbar puncture: a retrospective cohort study

   AUC (95% CI) S Sp  + LH -LH PPV NPV
MENINGITIS Uncorrected WBC 0.91 (0.83–0.98) 1.00 0.35 1.54 0.00 0.06 1.00
RBC:WBC 500:1 0.92 (0.81–1.00) 0.93 0.81 4.87 0.08 0.15 1.00
RBC:WBC 1000:1 0.92 (0.84–1.00) 0.93 0.64 2.58 0.11 0.09 1.00
RBC:WBC 400:1 0.92 (0.82–1.00) 0.93 0.84 5.99 0.08 0.18 1.00
Peripheral blood WBC 0.93 (0.84–1.00) 0.92 0.90 9.44 0.09 0.24 1.00
BACTERIAL
MENINGITIS
Uncorrected WBC 0.93 (0.87–0.98) 1.00 0.38 1.60 0.00 0.04 1.00
RBC:WBC 500:1 0.97 (0.94–0.99) 1.00 0.80 5.07 0.00 0.12 1.00
RBC:WBC 1000:1 0.96 (0.93–0.99) 1.00 0.63 2.73 0.00 0.07 1.00
RBC:WBC 400:1 0.97 (0.95–0.99) 1.00 0.84 6.19 0.00 0.14 1.00
Peripheral blood WBC 0.98 (0.96–0.99) 1.00 0.90 9.56 0.00 0.18 1.00
VIRAL
MENINGITIS
Uncorrected WBC 0.84 (0.64–1.00) 1.00 0.37 1.59 0.00 0.02 1.00
RBC:WBC 500:1 0.79 (0.46–1.00) 0.75 0.79 3.53 0.32 0.03 1.00
RBC:WBC 1000:1 0.83 (0.60–1.00) 0.75 0.62 1.98 0.40 0.02 1.00
RBC:WBC 400:1 0.80 (0.49–1.00) 0.75 0.82 4.22 0.30 0.04 1.00
Peripheral blood WBC 0.82 (0.53–1.00) 0.75 0.87 5.59 0.29 0.06 1.00
  1. Abbreviations: AUC area under the curve, CI confidence interval, LH likelihood ratio, NPV negative predictive value, PPV positive predictive value, S sensitivity, Sp specificity