Table 2 Comparison of different correction formulas for the detection of bacterial and/or viral meningitis in neonates with traumatic LPs
AUC (95% CI) | S | Sp | + LH | -LH | PPV | NPV | ||
|---|---|---|---|---|---|---|---|---|
MENINGITIS | Uncorrected WBC | 0.91 (0.83–0.98) | 1.00 | 0.35 | 1.54 | 0.00 | 0.06 | 1.00 |
RBC:WBC 500:1 | 0.92 (0.81–1.00) | 0.93 | 0.81 | 4.87 | 0.08 | 0.15 | 1.00 | |
RBC:WBC 1000:1 | 0.92 (0.84–1.00) | 0.93 | 0.64 | 2.58 | 0.11 | 0.09 | 1.00 | |
RBC:WBC 400:1 | 0.92 (0.82–1.00) | 0.93 | 0.84 | 5.99 | 0.08 | 0.18 | 1.00 | |
Peripheral blood WBC | 0.93 (0.84–1.00) | 0.92 | 0.90 | 9.44 | 0.09 | 0.24 | 1.00 | |
BACTERIAL MENINGITIS | Uncorrected WBC | 0.93 (0.87–0.98) | 1.00 | 0.38 | 1.60 | 0.00 | 0.04 | 1.00 |
RBC:WBC 500:1 | 0.97 (0.94–0.99) | 1.00 | 0.80 | 5.07 | 0.00 | 0.12 | 1.00 | |
RBC:WBC 1000:1 | 0.96 (0.93–0.99) | 1.00 | 0.63 | 2.73 | 0.00 | 0.07 | 1.00 | |
RBC:WBC 400:1 | 0.97 (0.95–0.99) | 1.00 | 0.84 | 6.19 | 0.00 | 0.14 | 1.00 | |
Peripheral blood WBC | 0.98 (0.96–0.99) | 1.00 | 0.90 | 9.56 | 0.00 | 0.18 | 1.00 | |
VIRAL MENINGITIS | Uncorrected WBC | 0.84 (0.64–1.00) | 1.00 | 0.37 | 1.59 | 0.00 | 0.02 | 1.00 |
RBC:WBC 500:1 | 0.79 (0.46–1.00) | 0.75 | 0.79 | 3.53 | 0.32 | 0.03 | 1.00 | |
RBC:WBC 1000:1 | 0.83 (0.60–1.00) | 0.75 | 0.62 | 1.98 | 0.40 | 0.02 | 1.00 | |
RBC:WBC 400:1 | 0.80 (0.49–1.00) | 0.75 | 0.82 | 4.22 | 0.30 | 0.04 | 1.00 | |
Peripheral blood WBC | 0.82 (0.53–1.00) | 0.75 | 0.87 | 5.59 | 0.29 | 0.06 | 1.00 |