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Table 2 Mean levels of MMP7, GGT and other markers among the three study groups

From: Serum matrix metalloproteinase-7 levels in infants with cholestasis and biliary atresia

 

Diagnosis

 
 

Biliary atresia

healthy

non-BA cholestasis

P-valuea

Bilirubin total (mg/dl)

14.48 ± 4.84

___

13.88 ± 4.89

0.669

Bilirubin direct (mg/dl)

6.89 ± 3.54

___

5.72 ± 2.75

0.187

AST (U/L)

202.75 ± 89.14

___

285.77 ± 197.63

0.085

ALT(U/L)

119.1 ± 58.78

___

173 ± 120.58

0.070

ALP(U/L)

1765.1 ± 830.55

___

1042.21 ± 787.29

0.004

GGT(U/L)

551.73 ± 208.17

149.71 ± 58.53

274.04 ± 163.43

< 0.001*

Hemoglobin

13.54 ± 1.54

___

13.1 ± 2.21

0.441

MCV

91.24 ± 2.74

___

119.14 ± 165.9

0.446

WBC

8311.9 ± 2903.23

___

7243.9 ± 3098.28

0.220

PLT

295,000 ± 130,000.38

___

323,433.33 ± 165,451.04

0.514

MMP7 (ng/mL)

15.91 ± 6.64

0.49 ± 0.33

4.73 ± 2.59

< 0.001#

  1. Abbreviation: AST Aspartate aminotransferase, ALT Alanine aminotransferase, ALP Alkaline phosphatase, GGT Gamma-glutamyl transferase, MCV Mean corpuscular volume, WBC White blood cells, PLT Platelet (Thrombocyte) count, MMP7 matrix Metalloproteinase-7
  2. a Obtained from ANOVA for continuous variables. Values are mean ± SD (95% CI) or n (%)
  3. * Significant differences between the Biliary atresia and healthy groups (Pvalue < 0.001) and between the Biliary atresia and non-BA cholestasis groups (Pvalue < 0.001) and also between the healthy and non-BA cholestasis groups (Pvalue = 0.002) using Bonferroni test
  4. # Significant differences between the Biliary atresia and healthy groups (Pvalue < 0.001) and between the Biliary atresia and non-BA cholestasis groups (Pvalue < 0.001) and also between the healthy and non-BA cholestasis groups (Pvalue < 0.001) using Bonferroni test
  5. A significance level of 0.05 was considered (Pvalue < 0.05)