Table 1 Baseline characteristics of each group before intervention and over 15 years old and bone age 15 years (Mean ± SD)

FH (cm)

154.5 ± 1.4^a

151.6 ± 2.3^b

146.1 ± 2.3^c

< 0.001

FH SD score^a

−1.14 ± 0.22^a

−1.59 ± 0.36^b

−2.44 ± 0.36^c

< 0.001

MPH (cm)

159.5 ± 2

161.3 ± 3.2

160.3 ± 3

0.15

GH therapy before EE (month)

37.8 ± 6

52.9 ± 8

–

–

 Primary

−3 ± 0.5

–

–

 Final

−2.3 ± 0.3^a

−2.8 ± 0.5^b

−3.1 ± 0.6^b

< 0.001

 Primary

−3.5 ± 0.7

−3.4 ± 0.7

–

–

 Final

− 2.6 ± 0.4^a

−2.9 ± 0.4^a

−3.5 ± 0.5^b

< 0.001

 Primary

8.7 ± 0.2

8.7 ± 0.2

–

–

 Final

8.8 ± 0.1^a

8.7 ± 0.2^a

8.4 ± 0.2^b

< 0.001

 Primary

6.9 ± 0.4

6.7 ± 0.5

–

–

 Final

6.2 ± 0.3^a

5.9 ± 0.3^b

7.4 ± 0.4^c

< 0.001

 Primary

166 ± 0.2

176 ± 0.1

–

–

 Final

143 ± 27^a

155 ± 27^a

279 ± 49^b

< 0.001

 Primary

4.6 ± 0.1

4.9 ± 0.1

–

–

 Final

8.3 ± 1.9

8.6 ± 2.5

8.4 ± 0.2

0.862