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Table 2 Effect of the different interventions in the biochemical outcomes

From: Effect of physical therapy on bone remodelling in preterm infants: a multicenter randomized controlled clinical trial

  EGrlt
(n = 31)
EGpmc
(n = 31)
CG
(n = 34)
Pairwise comparation Mean differences CI95%
Lower bound Upper bound
NTx-urine (nm of BCE / mm of creatinine) Pre-treatment 4266.11 ± 1441.48 5409.33 ± 2724.29 4604.38 ± 1918.98 EGrlt = EGpmc -1143.2 -2435.8 149.36
EGrlt = CG -338.3 -1611.1 934.58
EGpmc = CG 805 -467.9 2077.8
2 weeks 5362.30 ± 2257.88 5759.57 ± 4094.29 4835.02 ± 2290.11 EGrlt = EGpmc -397.3 -2245.6 1451.1
EGrlt = CG 527.3 -1292.81 2347.4
EGpmc = CG 924.5 -895.5 2744.6
Post-treatment 5070.38 ± 2807.67 5529.16 ± 4016.74 4317.45 ± 2231.91 EGrlt = EGpmc -458.8 -2369.2 1451.6
EGrlt = CG 752.9 -1128.3 2634.2
EGpmc = CG 1211.7 -669.5 3092.9
NTx-serum (nm of BCE) Pre-treatment 457.01 ± 109.59 473.38 ± 95.84 487.71 ± 107.05 EGrlt = EGpmc -16.37 -122.31 89.6
EGrlt = CG -30.7 -130.08 68.7
EGpmc = CG -14.33 -120.27 91.61
Post-treatment 509.53 ± 98.3 494.63 ± 85.96 473.09 ± 80.11 EGrlt = EGpmc 14.9 -74.54 104.34
EGrlt = CG 36.44 -47.46 120.34
EGpmc = CG 21.54 -67.9 111
Beta-CTx (ng/ml) Pre-treatment 0.79 ± 0.21 0.95 ± 0.31 0.91 ± 0.32 EGrlt = EGpmc -0.16 -0.45 0.13
EGrlt = CG -0.122 -0.4 0.15
EGpmc = CG 0.038 -0.25 0.33
Post-treatment 0.87 ± 0.19 0.94 ± 0.22 0.88 ± 0.26 EGrlt = EGpmc -0.065 -0.29 0.16
EGrlt = CG -0.005 -0.22 0.21
EGpmc = CG 0.059 -0.17 0.29
OC (ng/ml) Pre-treatment 61.56 ± 28.11 78.1 ± 34.44 78.18 ± 31.51 EGrlt = EGpmc -16.543 -48.1 14.97
EGrlt = CG -16.62 -46.74 13.5
EGpmc = CG -0.077 -32.12 31.97
Post-treatment 99.74 ± 34.05 97.35 ± 36.44 86.12 ± 24.52 EGrlt = EGpmc 2.397 -29.8 34.6
EGrlt = CG 13.62 -17.16 44.4
EGpmc = CG 11.222 -21.52 43.96
  1. *p < 0.05 for differences between groups. CG  Control Group, EGpmc  Experimental group treated with passive mobilizations with gentle joint compression, EGrlt  Experimental group treated with reflex locomotion therapy, CI95%  95% Confidence Interval, NTx N-Telopeptides of collagen bonds. Beta-CTx: C-telopeptides of collagen bonds, OC Osteocalcin, nm Nanometres, mm Millimetres, BCE Bone collagen equivalents, ng Nanogram, ml Millilitres. Data is presented as Mean ± SD