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Fig. 1 | BMC Pediatrics

Fig. 1

From: Isolated steroid-resistant nephrotic syndrome in a Chinese child carrying a de novo mutation in WT1 gene:a case report and literature review

Fig. 1

Renal pathology of the proband Pathological findings on periodic acid-Schiff (PAS) staining: mild focal segmental mesangial cell proliferation and mesangial matrix expansion, no proliferation of endothelial cells, no thickened basement membrane, patchy atrophy of tubules, vacuolar and granular degeneration and shedding of tubule epithelial cells, shedding of brush border, visible protein casts, red blood cells visible in the lumen of focal tubules; diffuse interstitial edema with infiltration of mainly monocytes/lymphocytes, multifocal fibrosis; and endothelial thickening of arterioles. Immunofluorescence findings: C3 deposition in the mesangial area and capillary wall; and negative for IgG, IgA, IgM, C1q, Fib, HBsAg, and HBcAg

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