Application of coagulation parameters at the time of necrotizing enterocolitis diagnosis in surgical intervention and prognosis

Table 2 Hematological comparison between medical treatment and surgical intervention

Blood test parameters	Overall (N = 114)	Surgical intervention (N = 46)	Medical treatment (N = 68)	P value
General blood examination
WBC (× 10⁹/L)^a	9.64 (6.80,13.06)	8.93 (5.60,11.16)	10.19 (7.18,13.68)	0.041
HB (g/L)^c	140.85 ± 32.02	133.20 ± 28.31	146.03 ± 33.52	0.035
PLT (× 10⁹/L)^a	277.0 (157.8,406.5)	163.0 (85.5,305.8)	328.0 (256.3,433.8)	< 0.001
CRP (mg/L)^b				0.026
< 8	68 (59.6)	21(45.7)	47 (69.1)
8 ~ 20	18 (15.8)	8 (17.4)	10 (14.7)
> 20 ~ 50	19 (16.7)	10 (21.7)	9 (13.2)
> 50	9 (7.9)	7 (15.2)	2 (2.9)
PCT (ug/L)^a	0.67 (0.15,4.39)	1.83 (0.58,12.75)	0.33 (0.12,2.65)	< 0.001
Coagulation assessment
PT (s)^a	15.6 (13.3,19.5)	18.5 (15.6,20.4)	14.3 (13.1,16.5)	< 0.001
PT-INR^a	1.08 (0.92,1.22)	1.12 (1.01,1.34)	1.01 (0.92,1.18)	0.008
APTT (s)^c	39.42 ± 7.02	44.07 ± 7.07	36.27 ± 4.97	< 0.001
Fib (g/L)^a	1.22 (1.06,1.51)	1.11 (1.00,1.31)	1.34 (1.13,1.62)	< 0.001
TT (s)^a	20.4 (17.9,24.9)	20.7 (17.7,25.7)	20.1 (17.9,24.5)	0.540
DD (mg/L)^a	1.22 (0.91,5.19)	1.42 (1.07,21.59)	1.12 (0.79,1.40)	< 0.001
FDP (μg/dL)^a	7.76 (4.73,11.37)	7.69 (4.65,11.22)	7.80 (4.58,11.80)	0.887

WBC White blood cell count, HB Hemoglobin, PLT Platelet count, CRP C-reactive Protein, PCT Procalcitonin, PT Prothrombin Time, PT-INR PT International Normalized Ratio, APTT Activated Partial Thromboplastin Time, Fib Fibrinogen, TT Thrombin Time, DD D-dimer, FDP Fibrinogendegradation Products
^aValues are presented as medians (IQR) and used Mann–Whitney U test;
^bChi-square test;
^cValues are presented as mean ± standard deviation and used Student’s t test

ISSN: 1471-2431