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Table 1 Clinical and demographic data of the participants

From: Insulin resistance, leptin and adiponectin in lean and hypothyroid children and adolescents with obesity

Parameters

Lean hypothyroid group (n = 30)

hypothyroid with obesity group (n = 30)

Control group (n = 30)

p-value

Age (years)

11 ± 2.17

10.6 ± 2.1

10. 8±2. 13

0. 8

Gender (M/F)

11:19

10:20

 12:18

0.87

Weight (Kg)

40 ± 9

57± 12.5a,b

39. 8± 7. 8

< 0.001

Height (cm)

140± 12.2

137 ± 10.5

141± 12. 8

0.78

BMI (Kg\m2)

20.2 ± 4.1

30 ± 4.3 a,b

19.9 ± 2.2

< 0.001

Pubertal development

 -Prepubertal

18 (60%)

16 (53.3%)

15 (50%)

0.651

 Pubertal

12 (40%)

14 (46. 7%)

15 (15%)

 

TSH (mU\L)

22.4± 7.1a

26.2 ± 9.6a

2. 8±0.67

< 0.001

fT3 (ng\dl)

2. 7±0.5a

2.5 ± 0.68a

3. 8±0.83

< 0.001

fT4 (μgl\dl)

8. 7±1.1a

8.1 ± 1.7a

18 ± 3.5

< 0.001

FBG (mg\dl)

83 ± 5.3

84 ± 5.4

82 ± 5.4

0.34

FBI (μIU\ml)

9.3 ± 2.3a

11.4 ± 2.4a,b

4 ± 0. 8

< 0.001

HOMA-IR

1.9 ± 0.4a

2.3 ± 0.44a,b

0. 8±0.15

< 0.001

Leptin (ng\ml)

15.3 ± 2.1a

17.4 ± 2a,b

7.2 ± 1.2

< 0.001

Adiponectin (ng\ml)

12.1 ± 2.3

9. 8±2a

12±2

0.034

  1. M/F Male to female, BMI Body mass index, TSH Thyroid stimulating hormone, fT3 free triiodothyronine, fT4 Free thyroxine, FBG Fasting blood glucose, FBI Fasting blood insulin, HOMA-IR Homeostasis model assessment method of insulin resistance
  2. a: significant difference compared to the control group, b: significant difference compared to the lean hypothyroid group