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Table 2 NRG1 expressions in the aganglionic colon of patients with HSCR and control colons

From: The impact of NRG1 expressions and methylation on multifactorial Hirschsprung disease

NRG1 isoform

HSCR

(ΔCT ± SD)

Control

(ΔCT ± SD)

ΔΔCT

(95% CI)

Fold change

p-value

Type I

14.47 ± 1.66

17.42 ± 1.51

-2.95(-4.23-(-1.67))

7.7*

 < 0.01

Type II

14.61 ± 2.43

16.29 ± 2.19

-1.69 (-3.56–0.18)

3.2

0.07

Type III

15.30 ± 2.80

16.32 ± 2.58

-1.02 (-3.47–1.44)

2.0

0.40

HRGβ1/HRGβ2

13.62 ± 3.42

14.75 ± 1.26

-1.13 (-3.75–1.48)

3.3*

0.01

HRGβ3

4.01 ± 0.94

4.88 ± 1.47

-0.87 (-1.77–0.03)

1.5

0.06

HRGα/NDF43

13.19 ± 3.97

13.50 ± 2.72

-0.31 (-3.29–2.68)

1.2

0.83

NDF43

16.53 ± 2.93

18.52 ± 1.14

-1.99 (-4.15–0.16)

3.9

0.07

  1. *p-value < 0.05