Table 1 NRG1 expressions in the ganglionic colon of patients with HSCR and control colons
From: The impact of NRG1 expressions and methylation on multifactorial Hirschsprung disease
NRG1 isoform | HSCR (ΔCT ± SD) | Control (ΔCT ± SD) | ΔΔCT (95% CI) | Fold change | p-value |
|---|---|---|---|---|---|
Type I | 13.32 ± 1.65 | 17.42 ± 1.51 | -4.10 (-5.38-(-2.82)) | 17.2* | < 0.01* |
Type II | 13.73 ± 2.02 | 16.29 ± 2.19 | -2.57 (-4.21-(-0.92)) | 3.2* | < 0.01* |
Type III | 13.47 ± 3.01 | 16.32 ± 2.58 | -2.84 (-5.42-(-0.27)) | 7.2* | 0.03* |
HRGβ1/ HRGβ2 | 13.01 ± 1.09 | 14.75 ± 1.26 | -1.74 (-3.04-(-0.44)) | 3.3* | 0.01* |
HRGβ3 | 3.50 ± 1.60 | 4.88 ± 1.47 | -1.38 (-2.56-(-0.19)) | 2.6* | 0.02* |
HRGα/NDF43 | 13.78 ± 3.00 | 13.50 ± 2.72 | 0.28 (-2.17–2.72) | 0.8 | 0.82 |
NDF43 | 16.80 ± 1.63 | 18.52 ± 1.15 | -1.72 (-3.03-(-0.40)) | 3.3* | 0.01* |