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Table 6 Sensitivity and specificity of combinations of WHO criteria and serum procalcitonin for diagnosis of pneumonia considering any abnormality on chest X-ray as gold standard for pneumonia

From: Role of procalcitonin in diagnosis of community acquired pneumonia in Children

Characteristics Sensitivity Specificity
Existing WHO criteria, n = 1273 331/586 (56.5) 455/687 (66.2)
Existing WHO criteria + Serum procalcitonin levels > 0.5 ng/mL, n = 337 55/209 (26.3) 114/128 (89.1)
Existing WHO criteria and/or Serum procalcitonin levels > 0.5 ng/mL; n = 1273 338/586 (57.7) 453/687 (65.9)
Existing WHO criteria + ve,
Serum procalcitonin levels > 0.5 ng/mL, applied serially, n = 297a
55/186 (29.6) 97/111 (87.4)
  1. Values are expressed as n(%)
  2. afirst the children were classified into pneumonia or no pneumonia according to WHO criteria; in children who had pneumonia by WHO criteria, serum procalcitonin levels (PCT) were used to determine presence or absence of pneumonia ( PCT > 0.5 ng/mL: pneumonia, PCT <  = 0.5 ng/mL: no pneumonia)