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Table 1 Characteristics of study sample

From: Biomarker combinations in predicting sepsis in hospitalized children with fever

Characteristics of the Study Sample Sepsis Group (n = 55) Non-sepsis Group (n = 110)
Clinical characteristics
 Age, months, median (IQR) 78 (33.50–163.00) 31.50 (26.24–40.00)
 Male, % (n) 52.7% (29) 42.7% (47)
 Day of illness at the time inclusiona, median (IQR) 3 (2–3) 3 (3–4)
 pSOFA score, % (n) 2 = 38.2% (21)
3 = 27.3% (15)
4 = 14.5% (8)
5 = 10.9% (6)
6 = 1.8% (1)
7 = 1.8% (1)
9 = 3.6% (2)
10 = 1.8% (1)
0 = 86
1 = 24
 ICU admission, % (n) 44.4% (24) 1.8% (2)
 Length of ICU stay, median (IQR) 3.5 (1–8) 1.5 (1–2)
 Required invasive ventilation, % (n) 9.2% (5)
 Length of hospital stay, days, median (IQR) 13 (9–15) 5 (5–6)
Laboratory characteristics
 WBC, median (IQR) x 109/L 10.92 (7.52–19.54) 13.6 (8.07–17.92)
 PLT, median (IQR) x 1012/L 219.00 (127.25–326.50) 279.00 (236.50–366.75)
 CRP, median (IQR), mg/L 162.00 (82.65–262.75) 42.90 (13.21–102.15)
 PCT, median (IQR), ng/mL 3.95 (0.69–12.94) 0.34 (0.11–2.28)
 Positive blood culture, % (n) 1.8% (1)
Inflammatory cytokine levels
 Eotaxin, median (IQR), pg/mL 61.77 (46.18–112.62) 83.66 (57.69–121.40)
 G-CSF, median (IQR), pg/mL 219.11 (58.56–524.93) 212.88 (94.66–710.43)
 IFN gamma, median (IQR), pg/mL 10.72 (4.34–25.08) 15.06 (7.70–53.43)
 IL-10, median (IQR), pg/mL 23.03 (11.46–73.61) 37.17 (20.16–81.79)
 IL-1ra, median (IQR), pg/mL 38.70 (17.27–143.67) 42.883 (14.20–102.13)
 IL-6, median (IQR), pg/mL 48.95 (24.45–235.00) 22.55 (8.63–58.55)
 IL-8, median (IQR), pg/mL 16.54 (8.82–36.40) 14.14 (6.91–21.17)
 IP-10, median (IQR), pg/mL 786.33 (347.72–2202.61) 975.72 (552.25–2103.36)
 MCP-1, median (IQR), pg/mL 393.44 (274.28–703.09) 472.96 (302.29–841.54)
 PAI-1, median (IQR), pg/mL 101,564.90 (117.88–150,633.47) 83,516.50 (143.80–163,213.34)
 sFAS, median (IQR), pg/mL 3171.12 (2592.33–4280.32) 2738.20 (2154.14–3552.89)
 sVACM-1, median (IQR), pg/mL 505,020.07 (1262.56–806,747.45) 352,718.78 (1081.54–1,034,808.95)
  1. aDay of illness – day after symptom onset as reported at the time of hospital admission by patients’ caregivers