From: Biomarker combinations in predicting sepsis in hospitalized children with fever
Characteristics of the Study Sample | Sepsis Group (n = 55) | Non-sepsis Group (n = 110) |
---|---|---|
Clinical characteristics | ||
Age, months, median (IQR) | 78 (33.50–163.00) | 31.50 (26.24–40.00) |
Male, % (n) | 52.7% (29) | 42.7% (47) |
Day of illness at the time inclusiona, median (IQR) | 3 (2–3) | 3 (3–4) |
pSOFA score, % (n) | 2 = 38.2% (21) 3 = 27.3% (15) 4 = 14.5% (8) 5 = 10.9% (6) 6 = 1.8% (1) 7 = 1.8% (1) 9 = 3.6% (2) 10 = 1.8% (1) | 0 = 86 1 = 24 |
ICU admission, % (n) | 44.4% (24) | 1.8% (2) |
Length of ICU stay, median (IQR) | 3.5 (1–8) | 1.5 (1–2) |
Required invasive ventilation, % (n) | 9.2% (5) | – |
Length of hospital stay, days, median (IQR) | 13 (9–15) | 5 (5–6) |
Laboratory characteristics | ||
WBC, median (IQR) x 109/L | 10.92 (7.52–19.54) | 13.6 (8.07–17.92) |
PLT, median (IQR) x 1012/L | 219.00 (127.25–326.50) | 279.00 (236.50–366.75) |
CRP, median (IQR), mg/L | 162.00 (82.65–262.75) | 42.90 (13.21–102.15) |
PCT, median (IQR), ng/mL | 3.95 (0.69–12.94) | 0.34 (0.11–2.28) |
Positive blood culture, % (n) | 1.8% (1) | – |
Inflammatory cytokine levels | ||
Eotaxin, median (IQR), pg/mL | 61.77 (46.18–112.62) | 83.66 (57.69–121.40) |
G-CSF, median (IQR), pg/mL | 219.11 (58.56–524.93) | 212.88 (94.66–710.43) |
IFN gamma, median (IQR), pg/mL | 10.72 (4.34–25.08) | 15.06 (7.70–53.43) |
IL-10, median (IQR), pg/mL | 23.03 (11.46–73.61) | 37.17 (20.16–81.79) |
IL-1ra, median (IQR), pg/mL | 38.70 (17.27–143.67) | 42.883 (14.20–102.13) |
IL-6, median (IQR), pg/mL | 48.95 (24.45–235.00) | 22.55 (8.63–58.55) |
IL-8, median (IQR), pg/mL | 16.54 (8.82–36.40) | 14.14 (6.91–21.17) |
IP-10, median (IQR), pg/mL | 786.33 (347.72–2202.61) | 975.72 (552.25–2103.36) |
MCP-1, median (IQR), pg/mL | 393.44 (274.28–703.09) | 472.96 (302.29–841.54) |
PAI-1, median (IQR), pg/mL | 101,564.90 (117.88–150,633.47) | 83,516.50 (143.80–163,213.34) |
sFAS, median (IQR), pg/mL | 3171.12 (2592.33–4280.32) | 2738.20 (2154.14–3552.89) |
sVACM-1, median (IQR), pg/mL | 505,020.07 (1262.56–806,747.45) | 352,718.78 (1081.54–1,034,808.95) |