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Fig. 2 | BMC Pediatrics

Fig. 2

From: Increased expression of OLFM4 and lysozyme during necrotizing enterocolitis in neonates: an observational research study

Fig. 2

Expression of OLFM4 and LYZ in NEC tissue. A-C NEC in a preterm infant (gestational age at birth: 26 weeks, birth weight: 800 g). OLFM4 was highly expressed in the crypts (arrow in B) and in the intestinal epithelial cells (arrow in A) and in immune cells, dispersed in the whole intestinal wall (A). LYZ was expressed in Paneth cells of the crypts (thin arrow in C) and in immune cells (e.g., macrophages, thick arrow in C). D-F NEC in a preterm infant (gestational age at birth: 31 weeks; birth weight: 1490 g). Massive expression of OLFM4 and extensive OLFM4 and LYZ staining of macrophages (arrows in E & F). G-I Expression of OLFM4 and LYZ in immune cells during NEC. G OLFM4 positive immune cells attached to the endothelial cells of a large vessel in the intestinal wall. H Neutrophils with expression of OLFM4 located in the intestinal wall. I LYZ-positive immune cells in the intestinal wall migrated from vessels into intramural tissue

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