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Table 4 Cox regression analysis of initial ART regimen change predictors among children in public health facilities of Bahir Dar city, Northwest Ethiopia, 2021(N = 459)

From: Incidence and predictors of initial antiretroviral therapy regimen change among children in public health facilities of Bahir Dar City, Northwest Ethiopia, 2021: multicenter retrospective follow-up study

Variables

Categories

Censored n (%)

IRC (event) n (%)

CHR (95%CI)

AHR (95%CI)

P-value

Sex

Male

70(28.57)

175(71.43)

1.14(.92,1.43)

1.28(1.02, 1.60)

.03

Female

74(34.58)

140(65.42)

1

1

.

Functional status

No limitation

121(31.84)

259(68.16)

1

1

.

Moderate or severe limitation

23(29.11)

56(70.89)

1.31(.98,1.75)

1.30(.97, 1.74)

.079

History tuberculosis

Yes

11(21.15)

41(78.85)

1.46(1.05, 2.03)

1.59(1.14,2.23)

.007

No

133(32.68)

274(67.32)

1

1

.

WHO clinical stage deterioration

Yes

2(25.00)

6(75.00)

1.78(.79,4.00)

1.69(.74, 3.83)

.210

No

142(31.49)

309(68.51)

1

1

.

Adherence

Good

129(36.54)

224(63.46)

1

1

.

Poor/fair

15(14.15)

91(85.85)

1.52(1.2,1.95)

1.49 (1.16, 1.92)

.002

ART drug regimen

NVP based

62 (24.41)

192(75.59)

1.32(1.05,1.66)

1.45(1.15, 1.84)

.002

EFV based

55 (31.61)

119(68.39)

1

1

.

DTG based

5 (83.33)

1(16.67)

.99(.14,7.2)

.34(.05, 2.54)

.296

LPVr based

22(88.00)

3(12.00)

.38(.12, 1.12)

.22(.07, .70)

.011

  1. Hint DTG-Dolutegravir, EFV Efavirenz, IRC initial regimen change, LPVr Lopinavire, NVP Nevirapine