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Table 3 Microbiological results

From: FilmArray® Meningoencephalitis panel in the diagnosis of central nervous system infections: stewardship and cost analysis in a paediatric hospital in Chile

Laboratory tests

Pre-intervention

n = 297

Post-intervention

n = 112

p valuea

Gram, n (%)

With bacteria

3 (1.0%)

3 (2.7%)

0.380

Without bacteria

293 (98.7%)

109 (97.3%)

 

No data

1 (0.3%)

 

Culture, n (%)

Positive

1 (0.3%)

2 (1.8%)

0.126

  S. pneumoniae

1 (50%)

 

  N. meningitidis

1 (100%)

 

  S. agalactiae

1 (50%)

 

Negative

296 (99.7%)

110 (98.2%)

 

Blood culture, n (%)

Positive

15 (5.1%)

6 (5.4%)

0.289

  S. pneumoniae

1 (16.7%)

 

  N. meningitidis

1 (6.7%)

1 (16.7%)

 

  S. agalactiae

2 (13.3%)

3 (50%)

 

  E. coli

2 (13.3%)

1 (16.6%)

 

  S. epidermis

3 (20.0%)

 

  S. aureus

4 (26.6%)

 

  S. parasanguinis

1 (6.7%)

 

  E. faecalis

1 (6.7%)

 

  S. pyogenes

1 (6.7%)

 

Negative

274 (92.3%)

101 (90.2%)

 

Unrealized-No data

8 (2.7%)

5 (4.5%)

 

Molecular testb, n (%)

Positive

10 (3.4%)

27 (24.1%)

< 0.001

  Enterovirus

3 (30%)

14 (51.9%)

 

  Parechovirus

3 (11.1%)

 

  HSV1

1 (10%)

 

  VZV

4 (40%)

 

  CMV

2 (20%)

 

  HHV-6

3 (11.1%)

 

  S. pneumoniae

4 (14.8%)

 

  N. meningitidis

1 (3.7%)

 

  H. influenzae

1 (3.7%)

 

  S. agalactiae

1 (3.7%)

 

Negative

31 (10.4%)

86 (76.8%)

 

Unrealized

256 (86.2%)

 

Overallc, n (%)

Positive

28 (9.4%)

30 (26.8%)

< 0.001

Negative

29 (9.4%)

82 (73.2%)

 

Unrealized

241 (81.1%)

 

Altered LCR, n (%)

76 (25.6)

53 (47.3)

< 0.001

Positivity in altered LCR, n (%)

7 (9.2%)

17 (32.1%)

0.001

  1. achi-square test
  2. b2016 only PCR vs. 2017-2018 PCR plus FAME
  3. cany microbiological test; Italics: relative frequencies, refers to the previous category in bold; bold: significant p values