“Association of MTHFR and MS/MTR gene polymorphisms with congenital heart defects in North Indian population (Jammu and Kashmir): a case–control study encompassing meta-analysis and trial sequential analysis”

Table 8 Overall meta-analysis and subgroup analysis by ethnicity for MTHFR C677T polymorphism

Genetic Model	Number of studies	Test of association			Heterogeneity			Egger's test p- value
Genetic Model	Number of studies	OR	95% CI	p-value	Model	p-value	I^2	Egger's test p- value
Overall
Allele contrast (T vs. C)	26	1.33	1.14–1.55	0.0002	Random	0.0001	0.7554	0.0259
Recessive model (TT vs. TC + CC)	25^a	1.49	1.83–1.87	0.0007	Random	0.0001	0.5828	0.1945
Dominant model (TT + TC vs. CC)	26	1.38	1.14- 1.69	0.001	Random	0.0001	0.696	0.0068
Homozygous model (TT vs CC)	25^a	1.75	1.26–2.44	0.001	Random	0.0001	0.7286	0.0699
Heterozygous model (TT vs CT)	25^a	1.34	1.11–1.60	0.002	Random	0.02	0.5157	0.6033
Caucasians
Allele contrast (T vs. C)	11	1.21	0.97–1.50	0.1	Random	0.0006	0.6755	0.1529
Recessive model (TT vs. TC + CC)	11	1.27	0.99–1.63	0.06	Fixed	0.1662	0.2933	0.8658
Dominant model (TT + TC vs. CC	11	1.24	0.95- 1.62	0.1	Random	0.003	0.6234	0.0657
Homozygous model (TT vs CC)	11	1.37	0.91- 2.07	0.1	Random	0.0237	0.5157	0.6033
Heterozygous model (TT vs CT)	11	1.78	0.91- 1.53	0.2	Fixed	0.5288	0	0.8349
Asians
Allele contrast (T vs. C)	15	1.42	1.15- 1.76	0.001	Random	0.0001	0.7988	0.0765
Recessive model (TT vs. TC + CC)	14^a	1.67	1.21–2.31	0.002	Random	0.0001	0.6958	0.1205
Dominant model (TT + TC vs. CC	15	1.50	1.12- 2.01	0.02	Random	0.0001	0.7438	0.0599
Homozygous model (TT vs CC)	14^a	2.12	1.30–3.47	0.003	Random	0.0001	0.8067	0.08
Heterozygous model (TT vs CT)	14^a	1.46	1.13–1.89	0.003	Random	0.03	0.4697	0.0834

^aIn one of the study, TT genotype is completely absent in one of the study group

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