Table 6 Association between selected gene polymorphisms and CHD
MODEL | OR (95% CI) | p-value |
|---|---|---|
MTHFR C677T polymorphism | ||
Co-dominant | ||
CT vs CC | 0.91 [0.27–3.12] | 0.879 |
TT vs CC | 4.09 [0.36–46.35] | 0.22 |
Dominant | ||
CT + TT vs CC | 1.23 [0.42–3.59] | 0.71 |
Recessive | ||
TT vs CT + CC | 4.12[0.36–46.63] | 0.234 |
Allelic | ||
T vs C | 1.49 [0.58–3.84] | 0.40 |
MTHFR G1793A polymorphism | ||
Co-dominant | ||
GA vs GG | 5.90 [2.46–14.11] | 0.00002b |
AA vs GG | Not possiblea | - |
Dominant | ||
GA + AA vs GG | 6.52 [2.75–15.43] | < 0.0001b |
Recessive | ||
AA vs GA + GG | Not possiblea | - |
Allelic | ||
A vs G | 5.68 [2.58–12.48] | < 0.0001b |
MS A2756G polymorphism | ||
Co-dominant | ||
AG vs AA | 1.68 [0.81–3.52] | 0.163 |
GG vs AA | 4.87 [0.43–55.71] | 0.20 |
Dominant | ||
AG + GG vs AA | 1.80 [0.88–3.69] | 0.11 |
Recessive | ||
GG vs AG + AA | 4.12[0.36–46.63] | 0.2 |
Allelic | ||
G vs A | 1.73 [0.93–3.22] | 0.08 |