“Association of MTHFR and MS/MTR gene polymorphisms with congenital heart defects in North Indian population (Jammu and Kashmir): a case–control study encompassing meta-analysis and trial sequential analysis”

Table 5 Showing genotypic and allelic distribution of selected gene polymorphisms among cases and controls

Category	Genotypes/Alleles (%)					χ²	p-value
	*MTHFR* (C677T) polymorphism
	CC (Wild)	CT (Hetero)	TT (Risk)	C (Wild)	T (Risk)
CHD Cases (n = 50)	44 (88%)	4 (8%)	2 (4%)	0.92	0.08	10.42	0.001*
Controls (n = 100)	90 (90%)	9 (9%)	1 (1%)	0.95	0.05	1.8	0.18
	*MTHFR* (G1793A) polymorphism
	GG (Wild)	GA (Hetero)	AA (Risk)	G (Wild)	A (Risk)
CHD Cases (n = 50)	29 (58%)	19 (38%)	2 (4%)	0.77	0.23	0.27	0.61
Controls (n = 100)	90 (90%)	10 (10%)	0	0.95	0.05	0.28	0.60
	MS (A2756G) gene polymorphism
	AA (Wild)	AG (Hetero)	GG (Risk)	A (Wild)	G (Risk)
CHD Cases (n = 50)	30 (60%)	18 (36%)	2 (4%)	0.78	0.22	0.12	0.73
Controls (n = 100)	73 (73%)	26 (26%)	1 (1%)	0.86	0.14	0.64	0.43

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