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Table 3 All children’s diagnoses for each ICD 10 chapter and presented by maternal age, use of ART and civil status

From: Maternal advanced age, single parenthood, and ART increase the risk of child morbidity up to five years of age

  Maternal age when born Conceived by ARTa   Single
  ≤ 39 years ≥40 years   No Yes   No Yes  
  n (%) n (%) P value n (%) n (%) P value n (%) n (%) P value
I Certain infectious and parasitic diseases    .506    .001    <.001
 No 11 264 (72.3) 5968 (72.8)   16 418 (72.7) 814 (68.1)   15 135 (72.9) 2097 (69.8)  
 Yes 4305 (27.7) 2235 (27.2)   6159 (27.3) 381 (31.9)   5632 (27.1) 908 (30.2)  
II Neoplasms    .958    .160    .146
 No 15 388 (98.8) 8107 (98.8)   22 319 (98.9) 1176 (98.4)   20 533 (98.9) 2962 (98.6)  
 Yes 181 (1.2) 96 (1.2)   258 (1.1) 19 (1.6)   234 (1.1) 43 (1.4)  
III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism    .394    .064    .665
 No 15 411 (99.0) 8110 (98.9)   22 345 (99.0) 1176 (98.4)   20 550 (99.0) 2971 (98.9)  
 Yes 158 (1.0) 93 (1.1)   232 (1.0) 19 (1.6)   217 (1.0) 34 (1.1)  
IV endocrine, nutritional and metabolic diseases    .082    .521    .830
 No 15 087 (96.9) 7982 (97.3)   21 913 (97.1) 1156 (96.7)   20 151 (97.0) 2918 (97.1)  
 Yes 482 (3.1) 221 (2.7)   664 (2.9) 39 (3.3)   616 (3.0) 87 (2.9)  
V Mental and behavioural disorders    .151    .129    .017
 No 15 138 (97.2) 7949 (96.9)   21 935 (97.2) 1152 (96.4)   20 189 (97.2) 2898 (96.4)  
 Yes 431 (2.8) 254 (3.1)   642 (2.8) 43 (3.6)   578 (2.8) 107 (3.6)  
VI Diseases of the nervous system    .551    .730    .206
 No 15 228 (97.8) 8033 (97.9)   22 090 (97.8) 1171 (98.0)   20 330 (97.9) 2931 (97.5)  
 Yes 341 (2.2) 170 (2.1)   487 (2.2) 24 (2.0)   437 (2.1) 74 (2.5)  
VII Diseases of the eye and adnexa    .183    .045    .126
 No 14 111 (90.6) 7391 (90.1)   20 441 (90.5) 1061 (88.8)   18 807 (90.6) 2695 (89.7)  
 Yes 1458 (9.4) 812 (9.9)   2136 (9.5) 134 (11.2)   1960 (9.4) 310 (10.3)  
VIII Diseases of the ear and mastoid process    .001    .172    .432
 No 12 311 (79.1) 6637 (80.9)   18 014 (79.8) 934 (78.2)   16 569 (79.8) 2379 (79.2)  
 Yes 3258 (20.9) 1566 (19.1)   4563 (20.2) 261 (21.8)   4198 (20.2) 626 (20.8)  
IX Diseases of the circulatory system    .650    .720    .865
 No 15 454 (99.3) 8138 (99.2)   22 405 (99.2) 1187 (99.3)   20 609 (99.2) 2983 (99.3)  
 Yes 115 (0.7) 65 (0.8)   172 (0.8) 8 (0.7)   158 (0.8) 22 (0.7)  
X Diseases of the respiratory system    <.001    .031    .930
 No 9281 (59.6) 5150 (62.8)   13 741 (60.9) 690 (57.7)   12 609 (60.7) 1822 (60.6)  
 Yes 6288 (40.4) 3053 (37.2)   8836 (39.1) 505 (42.3)   8158 (39.3) 1183 (39.4)  
XI Diseases of the digestive system    .807    <.001    .051
 No 13 715 (88.1) 7235 (88.2)   19 936 (88.3) 1014 (84.9)   18 334 (88.3) 2616 (87.1)  
 Yes 1854 (11.9) 968 (11.8)   2641 (11.7) 181 (15.1)   2433 (11.7) 389 (12.9)  
XII Diseases of the skin and subcutaneous tissue    .281    .371    .628
 No 13 601 (87.4) 7206 (87.8)   19 771 (87.6) 1036 (86.7)   18 185 (87.6) 2622 (87.3)  
 Yes 1968 (12.6) 997 (12.2)   2806 (12.4) 159 (13.3)   2582 (12.4) 383 (12.7)  
XIII Diseases of the musculoskeletal system and connective tissue    .354    .699    .218
 No 14 964 (96.1) 7864 (95.9)   21 683 (96.0) 1145 (95.8)   19 930 (96.0) 2898 (96.4)  
 Yes 605 (3.9) 339 (4.1)   894 (4.0) 50 (4.2)   837 (4.0) 107 (3.6)  
XIV Diseases of the genitourinary system    .894    .305    .398
 No 14 718 (94.5) 7758 (94.6)   21 354 (94.6) 1122 (93.9)   19 625 (94.5) 2851 (94.9)  
 Yes 851 (5.5) 445 (5.4)   1223 (5.4) 73 (6.1)   1142 (5.5) 154 (5.1)  
XVI Certain conditions originating in the perinatal period    .002    <.001    .063
 No 14 080 (90.4) 7315 (89.2)   20 371 (90.2) 1024 (85.7)   18 719 (90.1) 2676 (89.1)  
 Yes 1489 (9.6) 88 (10.8)   2206 (9.8) 171 (14.3)   2048 (9.9) 329 (10.9)  
XVII Congenital malformations, deformations and chromosomal abnormalities    <.001    .021    .065
 No 14 123 (90.7) 7324 (89.3)   20 392 (90.3) 1055 (88.3)   18 764 (90.4) 2683 (89.3)  
 Yes 1446 (9.3) 879 (10.7)   2185 (9.7) 140 (11.7)   2003 (9.6) 322 (10.7)  
XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified    .468    <.001    .005
 No 11 573 (74.3) 6133 (74.8)   16 869 (74.7) 837 (70.0)   15 531 (74.8) 2175 (72.4)  
 Yes 3996 (25.7) 2070 (25.2)   5708 (25.3) 358 (30.0)   5236 (25.2) 830 (27.6)  
XIX Injury, poisoning and certain other consequences of external causes    .001    .921    .089
 No 11 434 (73.4) 6182 (75.4)   16 729 (74.1) 887 (74.2)   15 351 (73.9) 2265 (75.4)  
 Yes 4135 (26.6) 2021 (24.6)   5848 (25.9) 308 (25.8)   5416 (26.1) 740 (24.6)  
Outpatient visits    0.743    0.041    0.004
 0-10 13776 (88.5) 7270 (88.6)   20010 (88.6) 1036 (86.7)   18433 (88.8) 2613 (87.0)  
 11- 1793 (11.5) 953 (11.4)   2567 (11.4) 159 (13.3)   2334 (11.2) 392 (13.0)  
Inpatient visits    0.203    0.194    0.717
 0-1 13653 (87.7) 7240 (88.3)   19857 (88.0) 1036 (86.7)   18258 (87.9) 2635 (87.7)  
 2- 1916 (12.3) 964 (11.7)   2720 (12.0) 159 (13.3)   2509 (12.1) 370 (12.3)  
ANY MORBIDITYb    .004    <.001    .625
 No 3222 (20.7) 1831 (22.3)   4858 (21.5) 195 (16.3)   4404 (21.2) 649 (21.6)  
 Yes 12 347 (79.3) 6372 (77.7)   17 719 (78.5) 1000 (83.7)   16 363 (78.8) 2356 (78.4)  
ANY MORBIDITYb excl chap XVI    .002    <.001    .924
 No 3433 (22.2) 1954 (23.8)   5181 (22.9) 206 (17.2)   4704 (22.7) 683 (22.7)  
 Yes 12 136 (77.9) 6249 (76.2)   17 369 (77.1) 989 (82.8)   16 063 (77.3) 2322 (77.3)  
  1. a Assisted reproductive technology (ART): ovulation induction, in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with own or donated gametes, embryo donation
  2. b Any morbidity: the presence of any diagnosis within any of ICD-10 chapters I to XIX