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Table 2 Estimates of life-years after diagnosis, QALYs (Discounted) and Costs (Discounted)

From: Clinical and economic impact of molecular testing for BRAF fusion in pediatric low-grade Glioma

Variable

Intervention

Control

Delta (Intervention-Control)

No Radiation Benefit

Life-years

40.08 (33.19;45.76)

39.01 (32.94;44.38)

1.07 (0;2.39)

QALY

11 (9.16;12.59)

10.62 (9.04;12.03)

0.38 (0.08;0.77)

Total Cost

$215,358 ($159,507; $232,728)

$216,742 ($161,250; $234,069)

$-1384 ($-3486; $1204)

PLGG

$90,839 ($75,023; $108,612)

$90,244 ($74,885; $107,176)

$595 ($106; $2083)

AE

$124,519 ($76,439; $151,351)

$126,498 ($78,418; $153,232)

$-1979 ($-4414; $1017)

Radiation Benefit

Life-years

42.05 (34.98;47.29)

41.44 (35.8;46.09)

0.61 (−0.78;2.25)

QALY

11.46 (9.69;12.91)

11.18 (9.68;12.49)

0.28 (−0.11;0.72)

Total Cost

$217,393 ($157,671; $236,003)

$218,624 ($155,869; $237,155)

$-1232 ($-3508; $1938)

PLGG

$78,899 ($68,624; $91,119)

$75,259 ($66,745; $85,262)

$3640 ($984; $8397)

AE

$138,494 ($81,832; $160,740)

$143,366 ($84,549; $164,863)

$-4872 ($-10,600; $-146)

  1. Estimates reported with 95% Confidence Interval in brackets. All costs are given in Canadian dollars
  2. QALY: Quality-adjusted Life Years; PLGG: Pediatric Low-Grade Glioma; AE: Adverse Events