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Table 1 Characteristic of the included studies

From: Effectiveness of feeding supplementation in preterm infants: an overview of systematic reviews

Author (Year) Objectives Study designs NO. of studies/Sample size Type of participants Period of supplementation Effectiveness of intervention Overall quality of SRs
Pammi et al. (2020) To assess the effect and safety of lactoferrin to prevent LOS and NEC in preterm infants RCTs and quasi-RCTs 12/5425 GW<37w NR B, D, E, F high
Howlett et al.
(2019)
To assess the effectiveness and safety of supplementary inositol in preterm infants in reducing adverse neonatal outcomes. RCTs and quasi-RCTs 3/1177 GW<37w and/or BW<2500 g NR E, F high
Walsh et al. (2019) To assess the evidence form RCTs that dietary supplementation with iodine reduces mortality and morbidity in preterm infants RCTs or quasi-RCTs 2/1394 GW<37w NICU stay A, B, C, D, E, F high
Chi et al. (2019) To assess the effects of prebiptics in promoting health or preventing adverse health outcomes in preterm infants. RCTs 18/1322 GW<37w or BW<2500 g NR D, E, F high
Armannia et al.
(2019)
To determine whether administration of prebiotics reduces the incidence of hyperbilirubinarmia among term and preterm infants. RCTs or quasi-RCTs 3/154 (1) GW ≥37w
(2)35w ≤ GW<37w
(3)GW<37w
NICU stay C, D, E, F high
Amissah et al.
(2018)
To determine whether supplementation of human milk with fat to preterm infants improve a series of health outcomes without adverse effects. RCT 1/14 GW<37w Hospital stays A, D high
Amissah et al.
(2018)
To determine whether supplementation of human milk with protein to preterm infants improve a series of health outcomes without adverse effect. RCTs or quasi-RCTs 6/204 GW<37w Hospital stays A, C, D, E high
Amissah et al.
(2018)
To determine whether supplementation of human milk with Carbohydrate to preterm infants improve a series of health outcomes without adverse effect. Quasi-RCTs 1/75 GW<37w Hospital stays A, D, E high
Yang et al. (2018) To assess the effect of vitamin D on body development,immune function and disease prevention in preterm infants. RCTs 12/NR NR Within 21d of birth A, C, E high
Harding et al.
(2017)
To determine whether addition of calcium and phosphorus supplements to human milk leads to improved growth and bone metabolism of preterm infants RCTs and quasi-RCTs 1/40 GW<37w Hospital stays A, C, D high
Shah et al. (2017) To exam the effect of arginine supplementation on the incidence of NEC in preterm infants. RCTs and quasi-RCTs 3/285 GW<37w NICU stay A, B, E, F high
Aceti et al. (2017) To evaluate the effect of probiotics for LOS prevention in preterm infants. RCTs 25/5868 GW<37w and/or BW<2500 g NR E high
Moe-Byrne et al.
(2016)
To determine the effects of gluta mine supplementation on mortality and morbidity in preterm infants. RCTs and quasi-RCTs 12/2877 GW<37w NR A, B, D, E,F high
Moon et al. (2016) To assess whether supplementation of formula milk with LCPUFA is safe and of benefit to preterm infants. RCTs 17/2260 GW<37w NICU stay A, B high
AlFaleh et al.
(2014)
To compare the efficacy and safety of prophylactic enteral probiotics administration in the prevention of NEC or sepsis in preterm infants. RCTs or quasi-RCTs 24/5529 GW<37w and/or BW<2500 g NR A, B, D, E,F high
Young et al. (2010) To determine the effect of feeding preterm infants following hospital discharge with multi-nutrient fortified breast milk versus unfortified breast milk on growth and development. RCTs or quasi-RCTs 2/246 GW<37w BW<2500 g Hospital discharge A, B, D high
Verner et al.(2007) To assess the effect of providing supplemental taurine for enterally or parenterally fed preterm or low birth weight infants on growth and development. RCTs or quasi-RCTs 9/189 GW<37w BW<2500 g Within 28d of birth A, B, D, E,F high
  1. NR not reported; GW gestation week; BW birth weight
  2. A: Physical health; B: Neurodevelopment; C: Biochemical outcomes; D: Other health outcomes; E: Morbidity of any disease; F: All-cause mortality