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Table 3 Characteristics of eligible studies included in this systematic review

From: Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review

Study (year) Country

Study Design

Participant characteristics

Outcome assessment

Participants (n)

Drop out (%)

Age in years

Mean (SD)

% Female

Beighton scorea

Mean (SD)

Recruitment site

Treatment or intervention group

Control group

Duration (Follow-up b)

Bale

et al.

(2019)

[39]

UK

Randomised controlled trial

119

baseline

111

At 3months

105

At 12 months

7%

12%

9.4 (3.2)

55%

5.7 (1.4)

Children’s department at tertiary Hospital

therapy intervention

(Tertiary PT and OT x5 sessions)

Standard care (medical assessment and allied health referrals)

2 months

(1, 10 months)

Hsieh

et al.

(2018)

[40]

Taiwan

Randomised controlled trial

52

Baseline

50

At 3 months

4%

6.6 (0.6)

46%

7.5 (1.6)

Outpatient rehabilitation center – teaching hospital

Physical therapy & orthotics with customised insoles

Physical therapy & podiatry without customised insoles

3 months

Kemp

et al.

(2010)

[41]

UK

Randomised controlled trial

57

Baseline

32

At 3 months

44%

10.9 (2.5)

33%

5.8 (1.6)

Rheumatology Outpatient department

Psychosocial & physical therapy targeted to improve functional stability of symptomatic joints

Generalised

therapy to improve muscle strength & fitness

2 months

(3months follow-up)

Pacey et a1. (2013)

[42]

Australia

Randomised

controlled trial

29

Baseline

26 randomised

25

2 months

14%

12.1(2.9)

66%

7.1 (1.2)

Physiotherapy department in a teaching hospital

Physical therapy: Muscle strength & motion control performed into full range of knee hyperextension

Physical therapy:

Muscle strength & motion control performedinto knee extension neutral range

2 week baseline without treatment followed by 8 treatment sessions and home exercises over 2 months

Revivo et al. (2019)

[43]

UK

Pre-Post

retrospective

30

Baseline

26

2 months

13%

14.0 (2.8)

90%

>4

Hospital Outpatient multidisciplinary pain management clinic

Physical therapy, occupational therapy, psychology counselling, & weekly paediatric rehabilitation follow-up

None

1.5-2 months

Scheper

et al.

(2017) [44]

Australia

Observational longitudinal

101

Baseline

81

3 years

20%

11.5 ± 3.1

55%

7 ± 1.6

Tertiary hospital

Outpatients clinics

No restrictions on treatment of participants

None

3 years

  1. Abbreviations. GP: Generalised Physiotherapy; HTG : Hypermobility treatment group; NTG: Neutral treatment group; TP: Targeted Physiotherapy. PT = physiotherapy OT= occupational therapy
  2. a Based on a 9 point scale [28]. The score is combined for both treated and control
  3. b Follow-up is post-intervention