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Table 3 Characteristics of eligible studies included in this systematic review

From: Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review

Study (year) Country Study Design Participant characteristics Outcome assessment
Participants (n) Drop out (%) Age in years
Mean (SD)
% Female
Beighton scorea
Mean (SD)
Recruitment site Treatment or intervention group Control group Duration (Follow-up b)
Bale
et al.
(2019)
[39]
UK
Randomised controlled trial 119
baseline
111
At 3months
105
At 12 months
7%
12%
9.4 (3.2)
55%
5.7 (1.4) Children’s department at tertiary Hospital therapy intervention
(Tertiary PT and OT x5 sessions)
Standard care (medical assessment and allied health referrals) 2 months
(1, 10 months)
Hsieh
et al.
(2018)
[40]
Taiwan
Randomised controlled trial 52
Baseline
50
At 3 months
4% 6.6 (0.6)
46%
7.5 (1.6) Outpatient rehabilitation center – teaching hospital Physical therapy & orthotics with customised insoles Physical therapy & podiatry without customised insoles 3 months
Kemp
et al.
(2010)
[41]
UK
Randomised controlled trial 57
Baseline
32
At 3 months
44% 10.9 (2.5)
33%
5.8 (1.6) Rheumatology Outpatient department Psychosocial & physical therapy targeted to improve functional stability of symptomatic joints Generalised
therapy to improve muscle strength & fitness
2 months
(3months follow-up)
Pacey et a1. (2013)
[42]
Australia
Randomised
controlled trial
29
Baseline
26 randomised
25
2 months
14% 12.1(2.9)
66%
7.1 (1.2) Physiotherapy department in a teaching hospital Physical therapy: Muscle strength & motion control performed into full range of knee hyperextension Physical therapy:
Muscle strength & motion control performedinto knee extension neutral range
2 week baseline without treatment followed by 8 treatment sessions and home exercises over 2 months
Revivo et al. (2019)
[43]
UK
Pre-Post
retrospective
30
Baseline
26
2 months
13% 14.0 (2.8)
90%
>4 Hospital Outpatient multidisciplinary pain management clinic Physical therapy, occupational therapy, psychology counselling, & weekly paediatric rehabilitation follow-up None 1.5-2 months
Scheper
et al.
(2017) [44]
Australia
Observational longitudinal 101
Baseline
81
3 years
20% 11.5 ± 3.1
55%
7 ± 1.6 Tertiary hospital
Outpatients clinics
No restrictions on treatment of participants None 3 years
  1. Abbreviations. GP: Generalised Physiotherapy; HTG : Hypermobility treatment group; NTG: Neutral treatment group; TP: Targeted Physiotherapy. PT = physiotherapy OT= occupational therapy
  2. a Based on a 9 point scale [28]. The score is combined for both treated and control
  3. b Follow-up is post-intervention