Table 13 Summary CAs with Significant Cannabinoid E-Values Categorical Variables

Cloacal exstrophy

1

GIT

Cannabis

4.85 (4.08, 5.77)

0.79 (0.75, 0.83)

386.7336

2.13E-86

9.17

7.61

Congenital hip dislocation

2

Limb

Cannabis

2.28 (2.08, 2.51)

0.56 (0.52, 0.60)

310.8170

7.27E-70

3.99

3.57

Coarctation of the aorta

3

CVS

Cannabis

1.38 (1.31, 1.45)

0.28 (0.24, 0.31)

152.3739

2.64E-35

2.10

1.95

Obstructive genitourinary defect

4

GUT

CBD

1.92 (1.63, 2.27)

0.48 (0.39, 0.56)

62.8480

2.22E-15

3.25

2.64

Turner syndrome

5

Chromosomes

Cannabis

1.54 (1.36, 1.75)

0.35 (0.26, 0.43)

46.5388

4.58E-12

2.45

2.06

Trisomy 21 (Down syndrome)

6

Chromosomes

Cannabis

1.12 (1.08, 1.16)

0.11 (0.08, 0.14)

45.1282

9.42E-12

1.49

1.39

Diaphragmatic hernia

7

Body Wall

Cannabis

1.24 (1.15, 1.34)

0.20 (0.13, 0.26)

31.3922

1.09E-08

1.80

1.57

Trisomy 18

8

Chromosomes

Cannabis

1.22 (1.13, 1.32)

0.18 (0.11, 0.24)

25.4031

2.41E-07

1.73

1.51

Small intestinal atresia/stenosis

9

GIT

Cannabis

1.22 (1.12, 1.33)

0.18 (0.11, 0.25)

21.0508

2.33E-06

1.75

1.49

Small intestinal atresia/stenosis

9

GIT

CBD

1.26 (1.14, 1.39)

0.21 (0.12, 0.28)

20.5107

5.93E-06

1.83

1.54

Hirschsprung disease (congenital megacolon)

10

GIT

Cannabis

1.46 (1.24, 1.72)

0.31 (0.19, 0.42)

20.2790

3.50E-06

2.27

1.77

Pulmonary valve atresia

11

CVS

CBD

1.35 (1.18, 1.55)

0.26 (0.15, 0.35)

19.4818

1.02E-05

2.04

1.64

Holoprosencephaly

12

Face

Cannabis

1.27 (1.12, 1.43)

0.21 (0.11, 0.30)

14.9227

5.94E-05

1.86

1.50

Pulmonary valve atresia

13

CVS

Cannabis

1.28 (1.13, 1.45)

0.22 (0.11, 0.31)

14.7343

6.56E-05

1.87

1.50

Congenital posterior urethral valves

14

GUT

Cannabis

1.33 (1.15, 1.54)

0.25 (0.13, 0.35)

14.5658

7.18E-05

1.99

1.56

Cloacal exstrophy

15

GIT

CBD

1.30 (1.12, 1.51)

0.23 (0.11, 0.34)

11.9548

5.45E-04

1.92

1.48

Trisomy 13

16

Chromosomes

Cannabis

1.22 (1.09, 1.38)

0.18 (0.08, 0.27)

11.7980

3.18E-04

1.75

1.41

Trisomy 21 (Down syndrome)

17

Chromosomes

CBD

1.06 (1.02, 1.09)

0.05 (0.02, 0.09)

9.4889

0.0021

1.30

1.16

Double outlet right ventricle

18

CVS

Cannabis

1.21 (1.07, 1.36)

0.17 (0.06, 0.27)

9.2314

0.0013

1.70

1.34

Clubfoot

19

Limb

CBD

1.10 (1.03, 1.18)

0.09 (0.03, 0.15)

7.9686

0.0048

1.43

1.20

Deletion 22q11.2

20

Chromosomes

Cannabis

1.36 (1.09, 1.68)

0.26 (0.09, 0.41)

7.8339

0.0028

2.05

1.42

Clubfoot

21

Limb

Cannabis

1.07 (1.01, 1.14)

0.07 (0.01, 0.12)

6.0907

0.0077

1.36

1.14

Cleft lip with and without cleft palate

22

Face

CBD

1.52 (1.08, 2.14)

0.34 (0.07, 0.53)

5.8113

0.0159

2.41

1.37

Esophageal atresia/tracheoesophageal fistula

23

GIT

Cannabis

1.11 (1.02, 1.21)

0.10 (0.02, 0.17)

5.4545

0.0112

1.45

1.15

Single ventricle

24

CVS

Cannabis

1.23 (1.03, 1.46)

0.19 (0.03, 0.32)

5.4301

0.0113

1.76

1.22

Biliary atresia

25

GIT

CBD

1.20 (1.02, 1.40)

0.17 (0.02, 0.29)

5.1462

0.0233

1.69

1.18

Biliary atresia

25

GIT

Cannabis

1.19 (1.02, 1.39)

0.16 (0.02, 0.28)

5.0640

0.0141

1.67

1.17

Hypoplastic left heart syndrome

26

CVS

Cannabis

1.10 (1.01, 1.19)

0.09 (0.01, 0.16)

4.8102

0.0164

1.42

1.11

Epispadias

27

GUT

Cannabis

1.31 (1.03, 1.67)

0.24 (0.03, 0.40)

4.7877

0.0166

1.95

1.20

Diaphragmatic hernia

28

Body Wall

CBD

1.09 (1.00, 1.17)

0.08 (0.00, 0.15)

4.3354

0.0373

1.39

1.07

Double outlet right ventricle

29

CVS

CBD

1.16 (1.01, 1.33)

0.14 (0.01, 0.25)

4.3080

0.0379

1.58

1.10

Trisomy 13

30

Chromosomes

CBD

1.14 (1.00, 1.28)

0.12 (0.00, 0.22)

4.1053

0.0427

1.53

1.07

Single ventricle

31

CVS

CBD

1.22 (1.00, 1.50)

0.18 (0.00, 0.33)

3.9021

0.0482

1.75

1.04