Table 11 Summary Single CAs with Significant Cannabinoid E-Values Continuous Variables

Congenital hip dislocation

1

Limb

CBD

298.2937

55.1100

5.4127

0.0000

3.8459

9.00E+30

7.53E+19

Small intestinal atresia/stenosis

2

GIT

CBD

61.6605

12.7480

4.8369

0.0000

1.1814

8.48E+20

3.86E+12

Trisomy 21 (Down syndrome)

3

Chromosomes

Cannabis

221.1194

25.4625

8.6841

0.0000

10.2305

6.97E+08

8.30E+06

Biliary atresia

4

GIT

CBD

10.9598

2.9445

3.7222

0.0002

0.3922

2.22E+11

3.48E+05

Interrupted aortic arch

5

CVS

Cannabis

15.4036

3.1814

4.8418

0.0000

0.8305

4.28E+07

4.68E+04

Obstructive genitourinary defect

6

GUT

CBD

486.0939

176.6878

2.7511

0.0072

13.0815

9.69E+14

3.51E+04

Hirschsprung disease (congenital megacolon)

7

GIT

CBD

38.1800

14.1676

2.6949

0.0084

1.0029

2.22E+15

2.67E+04

Clubfoot

8

Limb

Cannabis

94.0309

21.7820

4.3169

0.0000

5.4311

1.39E+07

1.10E+04

Trisomy 13

9

Chromosomes

Cannabis

75.1394

14.1320

5.3170

0.0000

5.1679

1.11E+06

8.58E+03

Congenital posterior urethral valves

10

GUT

Cannabis

23.9399

6.0470

3.9590

0.0001

1.6001

1.64E+06

1.96E+03

Trisomy 18

11

Chromosomes

Cannabis

126.9696

26.3799

4.8131

0.0000

10.0424

1.99E+05

1.85E+03

Esophageal atresia/tracheoesophageal fistula

12

GIT

Cannabis

8.8449

1.8993

4.6570

0.0000

0.7176

1.49E+05

1.34E+03

Hypospadias

13

GUT

Cannabis

277.1790

62.0518

4.4669

0.0000

23.4595

9.34E+04

842.36

Rectal and large intestinal atresia/stenosis

14

GIT

CBD

26.0458

8.9678

2.9044

0.0040

1.3051

1.54E+08

751.61

Diaphragmatic hernia

15

Body Wall

CBD

21.8501

7.9675

2.7424

0.0065

1.1678

4.96E+07

263.36

Deletion 22q11.2

16

Chromosomes

Cannabis

6.6430

2.1356

3.1106

0.0024

0.5153

2.49E+05

155.04

Turner syndrome

17

Chromosomes

Cannabis

85.6995

27.3283

3.1359

0.0021

6.9321

1.54E+05

137.32

Epispadias

18

GUT

Cannabis

12.5446

4.8274

2.5986

0.0111

0.7392

1.02E+07

90.57

Renal agenesis/hypoplasia

19

GUT

Cannabis

27.3954

8.0283

3.4124

0.0007

3.0315

7.45E+03

66.37

Anotia/microtia

20

Face

Cannabis

37.2830

10.9541

3.4036

0.0008

4.1220

7.51E+03

65.76

Cleft palate alone

21

Face

Cannabis

24.1946

7.4701

3.2389

0.0014

2.7271

6.42E+03

48.45

Encephalocele

22

CNS

Cannabis

11.3770

3.4999

3.2507

0.0013

1.3138

5.29E+03

45.63

Aortic valve stenosis

23

CVS

Cannabis

17.8815

5.6987

3.1378

0.0019

2.1020

4.60E+03

36.41

Ventricular septal defect

24

CVS

Cannabis

166.2143

53.4999

3.1068

0.0021

19.9528

3.92E+03

32.64

Pulmonary valve atresia

25

CVS

Cannabis

9.4232

3.2900

2.8642

0.0047

1.0048

1.02E+04

29.43

Omphalocele

26

Body Wall

Cannabis

28.8975

9.4470

3.0589

0.0025

3.5144

3.55E+03

29.18

Hypoplastic left heart syndrome

27

CVS

Cannabis

10.7890

3.7873

2.8487

0.0047

1.4621

1.65E+03

15.88

Limb deficiencies (reduction defects)

28

Limb

Cannabis

21.4215

8.5782

2.4972

0.0134

2.6156

3.45E+03

9.53

Bladder exstrophy

29

GUT

Cannabis

1.0618

0.4420

2.4021

0.0170

0.1593

8.61E+02

5.62

Tetralogy of Fallot

30

CVS

Cannabis

9.9067

4.1188

2.4052

0.0168

1.6031

5.53E+02

5.16

Total anomalous pulmonary venous connection

31

CVS

Cannabis

3.9176

1.7901

2.1885

0.0299

0.4968

2.61E+03

3.71

Reduction deformity, Lower limbs

32

Limb

Cannabis

16.8233

8.1886

2.0545

0.0420

1.5723

3.39E+04

2.57

Coarctation of the aorta

33

CVS

Cannabis

22.5596

10.7794

2.0928

0.0372

4.0947

300.37

2.12

Atrial septal defect

34

CVS

Cannabis

285.3616

136.7781

2.0863

0.0378

51.3723

313.06

2.08

Spina bifida without anencephalus

35

CNS

THC

2.8769

0.8458

3.4015

0.0008

4.0422

3.23

1.96

Choanal atresia

36

Face

THC

0.4877

0.1646

2.9621

0.0033

0.7074

3.15

1.78

Anophthalmia/microphthalmia

37

CNS

THC

1.1940

0.4167

2.8651

0.0045

1.7156

3.17

1.74

Transposition of great arteries

38

CVS

CBD

19.6282

9.8766

1.9873

0.0479

1.4902

3.21E+05

1.71

Holoprosencephaly

39

Face

THC

8.0303

3.0912

2.5978

0.0104

10.1025

3.54

1.68

Congenital cataract

40

Face

Cannabis

5.9492

2.9939

1.9871

0.0479

1.0436

357.58

1.39

Single ventricle

41

CVS

THC

0.6263

0.3014

2.0780

0.0394

0.9759

2.99

1.22