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Table 10 E-Values by Substance

From: Geotemporospatial and causal inference epidemiological analysis of US survey and overview of cannabis, cannabidiol and cannabinoid genotoxicity in relation to congenital anomalies 2001–2015

Congenital Anomaly

Cigarettes E-Value

Binge Alcohol E-Value

Analgesics E-Value

Cocaine E-Value

Cannabis E-Value

Cannabidiol E-Value

Obstructive genitourinary defect

 

1.00

 

1.46

 

2.64

Pulmonary valve atresia

1.00

 

2.28

 

1.53

1.64

Small intestinal atresia/stenosis

  

1.00

1.00

1.49

1.54

Cloacal exstrophy

4.32

 

2.16

 

7.61

1.48

Cleft lip with and without cleft palate

1.00

 

1.70

1.00

 

1.37

Clubfoot

1.00

 

1.00

 

1.14

1.20

Biliary atresia

1.00

  

1.00

1.17

1.18

Trisomy 21 (Down syndrome)

 

1.00

1.00

1.46

1.49

1.16

Double outlet right ventricle

1.00

 

1.11

 

1.36

1.10

Diaphragmatic hernia

1.52

 

1.31

 

1.57

1.07

Trisomy 13

   

2.73

1.75

1.07

Single ventricle

  

1.00

 

1.30

1.04

Transposition of great arteries

1.59

 

1.54

 

1.00

1.00

Rectal and large intestinal atresia/stenosis

1.50

 

1.01

  

1.00

Hypoplastic left heart syndrome

1.44

 

1.26

 

1.20

1.00

Cleft lip alone

1.00

1.00

1.38

  

1.00

Hirschsprung disease (congenital megacolon)

1.00

 

1.00

1.00

1.77

1.00

Spina bifida without anencephalus

1.00

 

1.93

1.00

1.10

1.00

Anotia/microtia

  

1.93

2.43

1.00

1.00

Aortic valve stenosis

  

2.32

1.00

 

1.00

Atrioventricular septal defect

  

1.10

 

1.03

1.00

Congenital hip dislocation

 

1.00

 

2.69

3.57

1.00

Deletion 22q11.2

 

1.00

4.22

2.28

1.42

1.00

Patent ductus arteriosus

  

1.37

  

1.00

Total anomalous pulmonary venous connection

  

1.79

1.51

1.00

1.00

Trisomy 18

  

1.16

1.91

1.85

1.00

Atrial septal defect

4.38

 

1.89

   

Common truncus (truncus arteriosus)

2.99

 

1.00

   

Holoprosencephaly

2.80

   

1.60

 

Pyloric stenosis

2.64

 

3.00

   

Hypospadias

2.48

     

Choanal atresia

1.77

1.00

    

Hydrocephalus without spina bifida

1.73

1.00

  

1.00

 

Bladder exstrophy

1.67

 

1.00

 

1.00

 

Microcephalus

1.65

 

1.00

   

Renal agenesis/hypoplasia

1.62

     

Ventricular septal defect

1.61

     

Cleft palate alone

1.58

1.00

1.41

   

Craniosynostosis

1.53

 

1.13

   

Coarctation of the aorta

1.42

 

1.43

 

1.97

 

Dextro-transposition of great arteries (d-TGA)

1.36

     

Omphalocele

1.35

 

1.09

   

Cleft lip with cleft palate

1.33

 

1.88

   

Encephalocele

1.28

 

1.00

   

Tetralogy of Fallot

1.20

 

1.00

   

Reduction deformity, Lower limbs

1.20

 

1.00

   

Limb deficiencies (reduction defects)

1.06

 

1.06

   

Aniridia

1.00

 

1.90

1.53

1.00

 

Congenital posterior urethral valves

1.00

 

1.00

 

1.56

 

Ebstein anomaly

1.00

 

1.60

   

Esophageal atresia/tracheoesophageal fistula

1.00

1.00

1.00

1.00

1.15

 

Interrupted aortic arch

1.00

 

1.49

 

1.00

 

Amniotic Bands

  

1.26

   

Anencephalus

  

1.91

1.00

  

Anophthalmia/microphthalmia

 

1.00

1.39

1.35

  

Congenital cataract

  

1.00

   

Epispadias

 

1.00

 

1.25

1.20

 

Gastroschisis

  

2.12

   

Pulmonary valve atresia and stenosis

  

1.00

   

Reduction deformity, Upper limbs

  

1.00

   

Tricuspid valve atresia and stenosis

   

1.35

  

Turner syndrome

 

1.10

1.00

1.25

2.31