MISCO study n (%) | MIS-C USA11 n (%) | P valuea | MIS-C UK10 n (%) | P valuea | |
---|---|---|---|---|---|
Number of patients | 78 | 570 | 52 | ||
Patients in PICU | 78 (100) | 364 (63.9) | 38 (73) | ||
Age in years (median, IQR) | 7 (1 - 11) | 8 (4 - 12) | 4.6 (0.3 - 13.7) | ||
Age | N/R | ||||
< 5 years | 29/78 (37) | 5/52 (10) | 0.004 | ||
≥ 5 years | 49/78 (63) | 47/52 (90) | |||
Sex | |||||
Male | 46/78 (59) | 316/570 (55) | 0.55 | 31/52 (60) | 0.94 |
Female | 32/78 (41) | 254/570 (45) | 21/52 (40) | ||
Obesity | 23/78 (29.5) | 146/570 (26) | 0.46 | 5/51 (10) | 0.008 |
Symptoms of KD | |||||
Fever | 78/78 (100) | NA | 52/52 (100) | NA | |
Changes in the mouth and mucous membranes | 17/78 (22) | 201/570 (35) | 0.018 | ||
Lymphadenopathy | 18/78 (23) | 76/570 (13) | 0.02 | 9/46 (19.5) | 0.6 |
Conjunctival injection | 23/78 (29.5) | 276/570 (48) | 0.001 | 20/48 (42) | 0.16 |
Other symptoms | |||||
Diarrhea | 55/78 (70.5) | 303/570 (53) | 0.001 | 32/49 (65) | 0.53 |
Abdominal pain | 55/78 (70.5) | 353/570 (62) | 0.14 | 34/50 (68) | 0.76 |
Nausea/vomiting | 58/78 (74) | 352/570 (62) | 0.03 | 38/50 (76) | 0.83 |
Headache | 17/78 (22) | 186/570 (33) | 0.052 | 16/47 (34) | 0.13 |
Labs | |||||
Lymphopenia | 50/78 (64) | 202/570 (35) | 0.001 | ||
Thrombocytopenia | 28/78 (36) | 176/570 (31) | 0.37 | 16/50 (32) | 0.65 |
Cardiac complications | |||||
Shock | 68/78 (87%) | 202/570 (35) | 0.001 | ||
Elevated troponin | 38/75 (51%) | 176/570 (30.9) | 0.006 | ||
Elevated BNP | 27/33 (82%) | 246/570 (43) | 0.001 | ||
Cardiac dysfunction | 14/75 (19) | 207/510 (40.6) | 0.002 | ||
Coronary dilation | 19/75 (25) | 95/510 (18.6) | 0.17 | 10/37 (27) | 0.31 |
Pericardial effusion | 27/75 (36) | 122/510 (23.9) | 0.02 | 0.15 | |
Mitral regurgitation | 16/75 (21) | 130/510 (25.5) | 0.43 | 5/37 (13.5) | 0.21 |
Hypotension | 61/78 (78) | 282/570 (49.5) | 0.001 | 9/37 (24) | |
IVIG | 71/78 (91) | 424/570 (81) | 0.001 | 28/43 (65) | 0.004 |
Steroids | 55/78 (70.5) | 331/570 (63) | 0.03 | 24/44 (55) | 0.07 |
Mechanical ventilation | 22/78 (28) | 69/570 (13) | 0.001 | 14/52 (27) | 0.87 |
High-flow cannula | 24/78 (31) | NA | 23/52 (44) | 0.11 | |
Inotropic support | 59/78 (76) | 221/570 (42) | 0.001 | 25/49 (51) | 0.004 |
Death | 7/78 (9) | 10/570 (1.8) | 0.001 | 0/51 | NA |