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Table 4 Comparison of Colombian data with other studies

From: Mortality and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) associated with covid-19 in critically ill patients: an observational multicenter study (MISCO study)

  MISCO study
n (%)
MIS-C USA11 n (%) P valuea MIS-C UK10
n (%)
P valuea
Number of patients 78 570   52  
Patients in PICU 78 (100) 364 (63.9)   38 (73)  
Age in years (median, IQR) 7 (1 - 11) 8 (4 - 12)   4.6 (0.3 - 13.7)  
Age   N/R    
< 5 years 29/78 (37)    5/52 (10) 0.004
≥ 5 years 49/78 (63)    47/52 (90)
Sex      
Male 46/78 (59) 316/570 (55) 0.55 31/52 (60) 0.94
Female 32/78 (41) 254/570 (45)   21/52 (40)
Obesity 23/78 (29.5) 146/570 (26) 0.46 5/51 (10) 0.008
Symptoms of KD      
Fever 78/78 (100)   NA 52/52 (100) NA
Changes in the mouth and mucous membranes 17/78 (22) 201/570 (35) 0.018   
Lymphadenopathy 18/78 (23) 76/570 (13) 0.02 9/46 (19.5) 0.6
Conjunctival injection 23/78 (29.5) 276/570 (48) 0.001 20/48 (42) 0.16
Other symptoms      
Diarrhea 55/78 (70.5) 303/570 (53) 0.001 32/49 (65) 0.53
Abdominal pain 55/78 (70.5) 353/570 (62) 0.14 34/50 (68) 0.76
Nausea/vomiting 58/78 (74) 352/570 (62) 0.03 38/50 (76) 0.83
Headache 17/78 (22) 186/570 (33) 0.052 16/47 (34) 0.13
Labs      
Lymphopenia 50/78 (64) 202/570 (35) 0.001   
Thrombocytopenia 28/78 (36) 176/570 (31) 0.37 16/50 (32) 0.65
Cardiac complications      
Shock 68/78 (87%) 202/570 (35) 0.001   
Elevated troponin 38/75 (51%) 176/570 (30.9) 0.006   
Elevated BNP 27/33 (82%) 246/570 (43) 0.001   
Cardiac dysfunction 14/75 (19) 207/510 (40.6) 0.002   
Coronary dilation 19/75 (25) 95/510 (18.6) 0.17 10/37 (27) 0.31
Pericardial effusion 27/75 (36) 122/510 (23.9) 0.02   0.15
Mitral regurgitation 16/75 (21) 130/510 (25.5) 0.43 5/37 (13.5) 0.21
Hypotension 61/78 (78) 282/570 (49.5) 0.001 9/37 (24)  
IVIG 71/78 (91) 424/570 (81) 0.001 28/43 (65) 0.004
Steroids 55/78 (70.5) 331/570 (63) 0.03 24/44 (55) 0.07
Mechanical ventilation 22/78 (28) 69/570 (13) 0.001 14/52 (27) 0.87
High-flow cannula 24/78 (31)   NA 23/52 (44) 0.11
Inotropic support 59/78 (76) 221/570 (42) 0.001 25/49 (51) 0.004
Death 7/78 (9) 10/570 (1.8) 0.001 0/51 NA
  1. a Chi square test or Fisher’s exact test, as applicable. KD: Kawasaki disease. N/R Not reported