Table 1 Clinical details at diagnosis and during follow-up in patients with PIBD-related CRC
From: Colorectal Cancer associated with pediatric inflammatory bowel disease: a case series
Patient No. | Patient 1 | Patient 2 | Patient 3 | Patient 4 |
|---|---|---|---|---|
Sex | M | M | M | M |
Age at first IBD diagnosis (years) | 12 | 11 | 5 | 16 |
Year of first diagnosis | 2000 | 2010 | 2001 | 2018 |
Type of IBD | CD | UC | VEOIBD | CD |
Genetic findings | NA | NA | Negative | NA |
Disease location (Paris classification) | L3 | E4 | L3 | L4 |
Perianal diseases | Fistula | Skin tag | (−) | (−) |
Luminal complications | Luminal stricture Bowel obstruction | (−) | (−) | Luminal narrowing Bowel obstruction |
Thiopurine (years) | 9.43 | 2.05 | 2.48 | 0.42 |
TNF inhibitor (years) | (−) | 3.44 | (−) | (−) |
Methotrexate (years) | (−) | 0.33 | (−) | (−) |
Other biologicals (years) | (−) | 0.71 (Golimumab) | (−) | (−) |
Surgery before cancer diagnosis | (−) | (−) | (−) | (−) |
Age at cancer diagnosis (years) | 24 | 20 | 15 | 17 |
Location | Transverse colon | Sigmoid colon | Ascending, sigmoid colon | Sigmoid colon |
Histological type | Mucinous carcinoma | Adenocarcinoma | Adenocarcinoma | Signet ring carcinoma |
Stage according to AJCC 8th | pT3N0M0 | pT1N0M0 | pT3N0M0 | pT4aN2bM1 |
Disease duration before cancer diagnosis (years) | 11.96 | 8.9 | 9.93 | 0.44 |
Last follow-up (year) | 2020 (Ongoing) | 2020 (Ongoing) | 2020 (Ongoing) | 2019 (Expired) |