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Table 3 Pancreatic functions and zinc level of TDT children according to their ferritin threshold

From: The effect of zinc deficiency and iron overload on endocrine and exocrine pancreatic function in children with transfusion-dependent thalassemia: a cross-sectional study

Variables Serum ferritin < 2500 (ng/ml)
N = 40
Serum ferritin ≥ 2500 (ng/ml)
N = 40
p Odds ratio (95% CI)
I. Endocrine pancreatic function
1) OGTT
Impaired: n (%) 6 (15%) 8 (20%) 0.02* 1.4 (0.4–4.5)
2) Insulin (μIu/ml):
Mean ± SD 12.9 ± 10.9 14.35 ± 10.68 0.6  
High: n (%) 16 (40%) 32 (80%) 0.001* 4.2 (1.08–16.6)
3) HOMA-IR
Mean ± SD 2.71 ± 2.29 3.1 ± 2.58 0.6  
High: n (%) 18 (45%) 14 (35%) 0.1 0.7 (0.3–1.6)
II. Exocrine pancreatic function
1) Serum amylase (Iu/ml):
Mean ± SD 57.55 ± 16.97 64.85 ± 18.81 0.2  
Low: n (%) 14 (35%) 12 (30%) 0.07 0.8 (0.3–2)
2) Serum lipase (u/l):
Mean ± SD 40.23 ± 9.91 38.6 ± 8.5 0.03*  
High: n (%) 8 (20%) 20 (50%) 0.005* 4 (1.5–10.8)
  1. CI confidence interval; OGTT Oral glucose tolerance test; HOMA-IR Homeostatic model assessment of insulin resistance
  2. * Statistical significance< 0.05