Table 4 Primary and secondary outcomes of infants treated with variable enemas, lipid enemas and no enemas

 FIP rate

24/201 (11.9%)

9/141 (6.4%)

0/57(0.0%)

I vs. II 0.09

I vs. III < 0.01

II vs. III 0.06

 Diagnosis of FIP (DOL)

6 (2–20)

12 (5–21)

–

I vs. II 0.23

I vs. III -

II vs. III -

- Terminal ileum

19/24 (79.2%)

5/9 (55.6%)

–

I vs. II 0.04

- Colon

3/24 (12.5%)

4/9 (44.4%)

–

I vs. III 0.39

- Not specified or no surgical treatment

2/24 (8.3%)

0

–

 NEC rate

6/201 (3.0%)

11/141 (7.8%)

2/57 (3.5%)

I vs. II 0.04

I vs. III 0.84

II vs. III 0.35

 Diagnosis of NEC (DOL)

12.5 (6–46)

7 (3–44)

7 (4–10)

I vs. II 0.59

I vs. III 0.29

II vs. III 0.51

 Diagnosis of ≥1 sepsis

37/201 (18.4%)

19/141 (13.5%)

8/57 (14.0%)

I vs. II 0.23

I vs. III 0.44

II vs. III 0.92

 First meconium (DOL)

1 (1–2)

2 (1–5)

1 (1–3)

I vs. II < 0.01

I vs. III 0.24

II vs. III < 0.01

 First transitional stool (DOL)

5 (2–14)

5 (3–16)

5 (2–9)

I vs. II 0.04

I vs. III 0.06

II vs. III < 0.01

 First normal stool (DOL)

7 (4–20)

7 (5–20)

6.5 (5–16)

I vs. II < 0.01

I vs. III 0.97

II vs. III < 0.01

 Sum of stools until first normal stool

20 (9–59)

19 (6–57)

20 (9–38)

I vs. II 0.19

I vs. III 0.64

II vs. III 0.62

 Sum of enemas until first normal stool

10 (2–41)

3 (1–22)

0

I vs. II < 0.01

I vs. III < 0.01

II vs. III < 0.01

 Days from birth to full enteral feeds

7 (5–110)

7 (5–47)

6 (4–98)

I vs. II 0.05

I vs. III < 0.01

II vs. III < 0.01

 Enteral intake on the 14th day of life (ml)

154 (0–186)

154 (0–186)

157 (100–175)

I vs. II 0.66

I vs. III 0.34

II vs. III 0.53

 Days from birth with IV line for PN

7 (5–109)

7 (5–79)

6 (5–98)

I vs. II 0.13

I vs. III < 0.01

II vs. III < 0.01

 N Infants with central IV lines

97/201 (48.3%)

79/141 (56.0%)

18/57 (31.6%)

I vs. II 0.16

I vs. III 0.03

II vs. III < 0.01

 Total days with central IV lines

8 (1–109)

8 (1–163)

6.5 (1–32)

I vs. II 0.27

I vs. III 0.01

II vs. III < 0.01