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Table 1 Demographics of the 23 patients who experienced CNS complications

From: Neuroimaging findings of posterior reversible encephalopathy syndrome (PRES) following haematopoietic stem cell transplantation in paediatric recipients

sex age diagnosis type of donor Chemot-
herapy
Radio-
therapy
GVHD prophylaxis Signs and symptoms CNS complications Neuroimaging findings of PFES
Male 10 ALL MUD yes no MTX + CsA seizure PRES Parieto-occipital involvement
Male 12 ALL MUD yes no MTX + CsA headache SDH Unilateral left convexity
Female 5 MDS Haplo. no no MMF + TAC + CYC impaired consciousness, headache leukoencephalopathy Symmetrical periventricular T2W/FLAIR hyperintensity
Female 0,75 SCID Haplo. no no MMF + TAC + CYC Nausea-
vomiting
SDH Unilateral right frontoparietal
Female 9 AA MRD no no MTX + CsA Headache, impaired consciousness, Fungal infection Multiple, small randomly distributed brain abscesses
Male 11 AML Haplo. yes no MMF + TAC + CYC Seizure, Visual symptoms, headache PRES Parieto-occipital involvement
Female 7 HLH Haplo. no no MMF + TAC + CYC Headache PRES Isolated Cerebellum involvement
Female 13 FAA MUD no no MTX + CsA Seizure, Nausea- vomiting PRES Parieto-occipital involvement
Male 15 Lymphoma MUD no TBI MTX + CsA Seizure, impaired consciousness PRES Parieto-occipital involvement
Female 8 ALL Haplo. yes TBI MTX + CsA + CYC Nausea- vomiting leukoencephalopathy Symmetrical periventricular T2W/FLAIR hyperintensity
Female 4 SA MUD no no MTX + CsA Headache, seizure leukoencephalopathy Symmetrical periventricular T2W/FLAIR hyperintensity
Male 7 ALL MUD yes TBI MTX + CsA Headache, impaired consciousness leukoencephalopathy Symmetrical periventricular T2W/FLAIR hyperintensity
Female 4 TM MSD no no MTX + CsA Headache,
Seizure, visual symptoms
PRES Parieto-occipital involvement
Female 8 TM MSD no no MTX + CsA seizure PRES Isolated basal ganglia involvement
Female 3 TM MUD no no MTX + CsA Visual symptoms, headache PRES Parieto-occipital involvement
Male 0,66 Osteopetrosis MRD no no MTX + CsA Nausea- vomiting SDH Unilateral left frontoparietal
Male 0,91 WA Haplo. no no MMF + TAC + CYC Seizure PRES Parieto-occipital involvement
Female 17 TM MRD no no MTX + CsA Headache,
Nausea-
vomiting
PRES İsolated frontal involvement
Female 5 TM MUD no no MTX + CsA Headache, seizure, impaired consciousness PRES Parieto-occipital involvement
Male 14 ALL MUD yes TBI MTX + CsA seizure PRES Parieto-occipital involvement
Male 13 TM MSD no no MTX + CsA Visual symptoms, Nausea- vomiting, seizure PRES Parieto-occipital involvement
Female 18 TM MUD no no MTX + CsA impaired consciousness, visual symptoms PRES Parieto-occipital involvement
Male 8 ALL MSD yes TBI MTX + CsA impaired consciousness, headache leukoencephalopathy Symmetrical periventricular T2W/FLAIR hyperintensity
  1. CsA: CYC: MMF: MTX: TAC: