Table 1 Demographics of the 23 patients who experienced CNS complications
sex | age | diagnosis | type of donor | Chemot- herapy | Radio- therapy | GVHD prophylaxis | Signs and symptoms | CNS complications | Neuroimaging findings of PFES |
|---|---|---|---|---|---|---|---|---|---|
Male | 10 | ALL | MUD | yes | no | MTX + CsA | seizure | PRES | Parieto-occipital involvement |
Male | 12 | ALL | MUD | yes | no | MTX + CsA | headache | SDH | Unilateral left convexity |
Female | 5 | MDS | Haplo. | no | no | MMF + TAC + CYC | impaired consciousness, headache | leukoencephalopathy | Symmetrical periventricular T2W/FLAIR hyperintensity |
Female | 0,75 | SCID | Haplo. | no | no | MMF + TAC + CYC | Nausea- vomiting | SDH | Unilateral right frontoparietal |
Female | 9 | AA | MRD | no | no | MTX + CsA | Headache, impaired consciousness, | Fungal infection | Multiple, small randomly distributed brain abscesses |
Male | 11 | AML | Haplo. | yes | no | MMF + TAC + CYC | Seizure, Visual symptoms, headache | PRES | Parieto-occipital involvement |
Female | 7 | HLH | Haplo. | no | no | MMF + TAC + CYC | Headache | PRES | Isolated Cerebellum involvement |
Female | 13 | FAA | MUD | no | no | MTX + CsA | Seizure, Nausea- vomiting | PRES | Parieto-occipital involvement |
Male | 15 | Lymphoma | MUD | no | TBI | MTX + CsA | Seizure, impaired consciousness | PRES | Parieto-occipital involvement |
Female | 8 | ALL | Haplo. | yes | TBI | MTX + CsA + CYC | Nausea- vomiting | leukoencephalopathy | Symmetrical periventricular T2W/FLAIR hyperintensity |
Female | 4 | SA | MUD | no | no | MTX + CsA | Headache, seizure | leukoencephalopathy | Symmetrical periventricular T2W/FLAIR hyperintensity |
Male | 7 | ALL | MUD | yes | TBI | MTX + CsA | Headache, impaired consciousness | leukoencephalopathy | Symmetrical periventricular T2W/FLAIR hyperintensity |
Female | 4 | TM | MSD | no | no | MTX + CsA | Headache, Seizure, visual symptoms | PRES | Parieto-occipital involvement |
Female | 8 | TM | MSD | no | no | MTX + CsA | seizure | PRES | Isolated basal ganglia involvement |
Female | 3 | TM | MUD | no | no | MTX + CsA | Visual symptoms, headache | PRES | Parieto-occipital involvement |
Male | 0,66 | Osteopetrosis | MRD | no | no | MTX + CsA | Nausea- vomiting | SDH | Unilateral left frontoparietal |
Male | 0,91 | WA | Haplo. | no | no | MMF + TAC + CYC | Seizure | PRES | Parieto-occipital involvement |
Female | 17 | TM | MRD | no | no | MTX + CsA | Headache, Nausea- vomiting | PRES | İsolated frontal involvement |
Female | 5 | TM | MUD | no | no | MTX + CsA | Headache, seizure, impaired consciousness | PRES | Parieto-occipital involvement |
Male | 14 | ALL | MUD | yes | TBI | MTX + CsA | seizure | PRES | Parieto-occipital involvement |
Male | 13 | TM | MSD | no | no | MTX + CsA | Visual symptoms, Nausea- vomiting, seizure | PRES | Parieto-occipital involvement |
Female | 18 | TM | MUD | no | no | MTX + CsA | impaired consciousness, visual symptoms | PRES | Parieto-occipital involvement |
Male | 8 | ALL | MSD | yes | TBI | MTX + CsA | impaired consciousness, headache | leukoencephalopathy | Symmetrical periventricular T2W/FLAIR hyperintensity |