Table 1 Search Strategy in PubMed

Ethics

1

Ethics [MeSH Terms]

149,276

2

ethic*[Title/Abstract]

144,284

3

1 OR 2

236,299

Specific Ethical Issues

4

Personal Autonomy [MeSH Terms] OR Informed Consent [MeSH Terms] OR Confidentiality [MeSH Terms] OR Privacy [MeSH Terms]

110,138

5

autonomy [Title/Abstract] OR consent [Title/Abstract] OR confidentiality [Title/Abstract] OR privacy [Title/Abstract] OR incidental finding*[Title/Abstract] OR variant* of unknown significance [Title/Abstract] OR secondary finding*[Title/Abstract]

130,365

6

4 OR 5

205384

7

3 OR 6

385419

Genome-wide sequencing

8

Whole genome sequencing [MeSH Terms]] OR Genomics [MeSH Terms]] OR Sequence Analysis, DNA [MeSH Terms]

351684

9

whole-genome sequencing [Title/Abstract] OR whole-exome sequencing [Title/Abstract] OR genome sequencing [Title/Abstract] OR exome sequencing [Title/Abstract] OR genomic sequencing [Title/Abstract] OR genomic test*[Title/Abstract] OR genomic stud*[Title/Abstract] OR complete genome sequencing [Title/Abstract] OR genome-scale sequencing [Title/Abstract]

53,146

10

8 OR 9

385161

11

7 AND 10

3894

With Filter from 14.4.2003 until 28.5.2021

3070