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Table 2 Comparison of possible associated factors with THOP between patients and controls

From: The factors associated with transient hypothyroxinemia of prematurity

Risk factors THOP group Control group P value
Participants, (n) 71 73  
BW (g) 1306,52 ± 446 1544,93 ± 498 < 0.001
Apgar score < 7 (5th minute) 34 (48) 24 (33) 0.066
Apgar score ≥ 7 (5th minute) 37 (52) 49 (67)  
Delivery type (C/S) 63 (89) 67 (92) 0.537
FGR 19 (27) 12 (16) 0.132
SGA 15 (21) 4 (5) 0.006
PRENATAL
 Maternal smoking 5 (7) 5 (7) 1.000
 IVF 8 (11) 7 (10) 0.955
 GDM 6 (9) 13 (18) 0.097
 Gestational hypertension 20 (28) 21 (29) 1.000
 Prenatal betamethasone treatment 47 (66) 48 (66) 1.000
MEDICINE
 Vancomycin+amikacin 9 (13) 5 (7) 0.238
 Ampicillin+gentamicin 36 (51) 41 (56) 0.511
 Surfactant 39 (55) 34 (46) 0.403
 Caffeine 59 (83) 57 (78) 0.582
 Dobutamine 8 (11) 3 (4) 0.106
 Dopamine 17 (24) 13 (18) 0.365
 Midazolam 23 (32) 21 (29) 0.637
 Fentanyl 4 (6) 2 (3) 0.385
 Paracetamol 3 (4) 2 (3) 0.679
 Ibuprofen 9 (13) 4 (6) 0,132
 Fluconazole prophylaxis 34 (48) 32 (44) 0.626
CLINICAL-DIAGNOSIS
 RDS 39 (55) 34 (56) 0.403
 IVH 24 (34) 12 (16) 0.022
 Pneumothorax 3 (4) 4 (5) 0.726
 PDA 12/59 (20)* 6/57 (11)* 0.144
 CHD 15/59 (25)* 5/57 (9)* 0.018
 ROP 3 (4) 1 (1) 0.448
 BPD 26 (37) 16 (22) 0.052
 Hypoglycemia 21 (30) 23 (31) 0.802
 Sepsis 7 (10) 9 (12) 0.837
TRANSFUSIONS
 ES transfusion 18 (25) 13 (18) 0.271
 TS transfusion 5 (7) 5 (7) 0.964
 FFP transfusion 23 (32) 19 (26) 0.401
CLINICAL APPLICATIONS
 Phototherapy 66 (93) 68 (93) 0.964
 Central catheter 57 (80) 57 (78) 0.905
 Ventilator support 31 (43) 28 (38) 0.517
 NIV support 48 (68) 54 (74) 0.511
  1. Data are given as numbers and (%), after decimal rounded to the greater side. Parameters ​​with p < 0.2 were included in univariate logistic regression analysis (dark stained ones)
  2. *Data are given as cases / total cases with echocardiographic examination
  3. Abbreviations: THOP transient hypothyroxinemia of prematüre; BW birth weight; C/S caesarean; FGR fetal growth retardation; SGA small for gestational age; IVF in vitro fertilization; GDM gestational diabetes; IVH intraventricular hemorrhage; PDA patent ductus arteriosus; CHD congenital heart disease; ROP premature retinopathy; BPD bronkopulmonary dysplasia; ES erirtosit suspension; TS thrombcyte suspension; FFP fresh frozen plasma; NIV non invasive ventilation