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Table 2 Comparison of possible associated factors with THOP between patients and controls

From: The factors associated with transient hypothyroxinemia of prematurity

Risk factors

THOP group

Control group

P value

Participants, (n)

71

73

 

BW (g)

1306,52 ± 446

1544,93 ± 498

< 0.001

Apgar score < 7 (5th minute)

34 (48)

24 (33)

0.066

Apgar score ≥ 7 (5th minute)

37 (52)

49 (67)

 

Delivery type (C/S)

63 (89)

67 (92)

0.537

FGR

19 (27)

12 (16)

0.132

SGA

15 (21)

4 (5)

0.006

PRENATAL

 Maternal smoking

5 (7)

5 (7)

1.000

 IVF

8 (11)

7 (10)

0.955

 GDM

6 (9)

13 (18)

0.097

 Gestational hypertension

20 (28)

21 (29)

1.000

 Prenatal betamethasone treatment

47 (66)

48 (66)

1.000

MEDICINE

 Vancomycin+amikacin

9 (13)

5 (7)

0.238

 Ampicillin+gentamicin

36 (51)

41 (56)

0.511

 Surfactant

39 (55)

34 (46)

0.403

 Caffeine

59 (83)

57 (78)

0.582

 Dobutamine

8 (11)

3 (4)

0.106

 Dopamine

17 (24)

13 (18)

0.365

 Midazolam

23 (32)

21 (29)

0.637

 Fentanyl

4 (6)

2 (3)

0.385

 Paracetamol

3 (4)

2 (3)

0.679

 Ibuprofen

9 (13)

4 (6)

0,132

 Fluconazole prophylaxis

34 (48)

32 (44)

0.626

CLINICAL-DIAGNOSIS

 RDS

39 (55)

34 (56)

0.403

 IVH

24 (34)

12 (16)

0.022

 Pneumothorax

3 (4)

4 (5)

0.726

 PDA

12/59 (20)*

6/57 (11)*

0.144

 CHD

15/59 (25)*

5/57 (9)*

0.018

 ROP

3 (4)

1 (1)

0.448

 BPD

26 (37)

16 (22)

0.052

 Hypoglycemia

21 (30)

23 (31)

0.802

 Sepsis

7 (10)

9 (12)

0.837

TRANSFUSIONS

 ES transfusion

18 (25)

13 (18)

0.271

 TS transfusion

5 (7)

5 (7)

0.964

 FFP transfusion

23 (32)

19 (26)

0.401

CLINICAL APPLICATIONS

 Phototherapy

66 (93)

68 (93)

0.964

 Central catheter

57 (80)

57 (78)

0.905

 Ventilator support

31 (43)

28 (38)

0.517

 NIV support

48 (68)

54 (74)

0.511

  1. Data are given as numbers and (%), after decimal rounded to the greater side. Parameters ​​with p < 0.2 were included in univariate logistic regression analysis (dark stained ones)
  2. *Data are given as cases / total cases with echocardiographic examination
  3. Abbreviations: THOP transient hypothyroxinemia of prematüre; BW birth weight; C/S caesarean; FGR fetal growth retardation; SGA small for gestational age; IVF in vitro fertilization; GDM gestational diabetes; IVH intraventricular hemorrhage; PDA patent ductus arteriosus; CHD congenital heart disease; ROP premature retinopathy; BPD bronkopulmonary dysplasia; ES erirtosit suspension; TS thrombcyte suspension; FFP fresh frozen plasma; NIV non invasive ventilation