Table 3 Impact of parental consanguinity on the characteristics and type of ALL patients with no associated disorder
Characteristics | Parental consanguinity (n = 51) | No parental consanguinity (n = 147) | Odds ratio (95% CI) | P-value |
|---|---|---|---|---|
Age of the patient | ||||
< 10 | 105 (69.53%) | 123 (83.67%) | 0.44 (0.25–0.77) | 0.00* |
≥ 10 | 46 (30.46) | 24 (16.32%) | ||
WBC count | ||||
< 50,000 | 144 (95.36%) | 141 (95.91%) | 0.87 (0.28–2.66) | 0.82 |
≥ 50,000 | 7 (4.63%) | 6 (4.08%) | ||
Hepatospleenomegaly | ||||
Yes | 56 (37.08%) | 51 (38.77%) | 1.11 (0.69–1.78) | 0.66 |
No | 95 (62.91%) | 96 (65.30%) | ||
Cardiotoxicity | ||||
Yes | 15 (9.93%) | 19 (12.92%) | 0.74 (0.36–1.52) | 0.41 |
No | 136 (90.06%) | 128 (87.07%) | ||
Sub-type of ALL | ||||
Pre-BALL | 132 (87.42%) | 125 (85.03%) | 1.22 (0.63–1.36) | 0.55 |
Pre-TALL | 19 (12.58%) | 22 (14.96%) | ||
BCR-ABL translocation | 1 (0.66%) | 0 | – | – |
Two primary cancers in the affected child | 1 (0.66%) | 0 | – | – |