Skip to main content

Table 4 ORs of mildly and markedly increased ALTa for impaired fasting glucose and lipid profile

From: Prevalence of increased transaminases and its association with sex, age, and metabolic parameters in children and adolescents with obesity – a nationwide cross-sectional cohort study

 

Mildly increased ALT, n = 3527

Markedly increased ALT, n = 907

OR (99% CI)

P value

OR (99% CI)

P value

Impaired fasting glucose

1.21 (0.91, 1.62)

0.085

1.62 (1.10, 2.40)

0.001

LDL

 Acceptable

Ref

 

Ref

 

 Borderline-high

1.20 (1.04, 1.39)

0.001

1.34 (1.06, 1.71)

0.002

 High

1.41 (1.20, 1.65)

< 0.001

1.77 (1.38, 2.27)

< 0.001

Total cholesterol

 Acceptable

Ref

 

Ref

 

 Borderline-high

1.17 (1.02, 1.33)

0.002

1.20 (0.97, 1.50)

0.028

 High

1.37 (1.14, 1.64)

< 0.001

1.80 (1.37, 2.36)

< 0.001

HDL

 Acceptable

Ref

 

Ref

 

 Low

1.25 (1.05, 1.49)

0.001

1.69 (1.33, 2.15)

< 0.001

Triglycerides

 Acceptable

Ref

 

Ref

 

 Borderline-high

1.16 (1.00, 1.34)

0.008

1.65 (1.28, 2.11)

< 0.001

 High

1.78 (1.54, 2.05)

< 0.001

3.06 (2.44, 3.84)

< 0.001

HOMAb

1.06 (1.04–1.09)

< 0.001

1.13 (1.09–1.17)

< 0.001

  1. Abbreviations: ALT alanine aminotransferase, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, HOMA homeostasis model assessment, OR odds ratio, CI confidence interval, Ref reference group
  2. All ORs were adjusted for age, sex, and the degree of obesity
  3. a Compared to individuals with normal ALT
  4. b Analyses were based on 5262 individuals who had HOMA data (individuals with normal ALT, n = 2655; mildly increased ALT, n = 2047; markedly increased ALT, n = 560)
Back to article page

BMC Pediatrics

ISSN: 1471-2431

Contact us