Prevalence of increased transaminases and its association with sex, age, and metabolic parameters in children and adolescents with obesity – a nationwide cross-sectional cohort study

Table 3 Metabolic characteristics of individuals in the obesity cohort

	All individuals	Normal ALT	Mildly increased ALT	Markedly increased ALT	P value¹	P value²	P value³
	(n = 9223)	(n = 4789)	(n = 3527)	(n = 907)	P value¹	P value²	P value³
Impaired fasting glucose	1897 (20.6)	916 (19.1)	718 (20.4)	263 (29.0)	0.163	< 0.001	< 0.001
LDL-C
Borderline-high	1902 (20.6)	943 (19.7)	758 (21.5)	201 (22.2)	< 0.001	< 0.001	0.015
High	1517 (16.5)	671 (14.0)	645 (18.3)	201 (22.2)
Total cholesterol
Borderline-high	2760 (29.9)	1396 (29.2)	1094 (31.0)	270 (29.8)	< 0.001	< 0.001	0.029
High	1183 (12.8)	534 (11.2)	491 (13.9)	158 (17.4)
Low HDL-C	1334 (14.5)	554 (11.6)	557 (15.8)	223 (24.6)
Triglycerides
Borderline-high	2126 (23.1)	1094 (22.8)	804 (22.8)	228 (25.1)	< 0.001	< 0.001	< 0.001
High	2445 (26.5)	956 (20.0)	1105 (31.3)	384 (42.3)

Abbreviations: ALT alanine aminotransferase, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, OR odds ratio, CI confidence interval
Differences between groups were assessed using the chi-square test
¹ Comparison between mildly increased ALT and normal ALT group
² Comparison between markedly increased ALT and normal ALT group
³ Comparison between markedly increased ALT and mildly increased ALT group