Table 2 Minor allelic, genotypic, and haplotype distributions of UGT1A1 polymorphism in studied patients (N = 69)
UGT1A1 polymorphism | Location | N | Frequency | PH-Wa |
|---|---|---|---|---|
TATA box (rs8175347) | promoter | 1 | ||
TA7 | 9 | 0.07 | ||
TA6 | 129 | 0.93 | ||
TA7/TA7 | 0 | 0 | ||
TA6/TA7 | 9 | 0.13 | ||
TA6/TA6 | 60 | 0.87 | ||
C.211 G > A (rs4148323) | Exon 1 | 1 | ||
A | 21 | 0.15 | ||
G | 117 | 0.85 | ||
A/A | 1 | 0.01 | ||
G/A | 19 | 0.28 | ||
G/G | 49 | 0.71 | ||
c.1091 C > T (rs34946978) | Exon 4 | 1 | ||
T | 3 | 0.02 | ||
C | 135 | 0.98 | ||
T/T | 0 | 0 | ||
C/T | 3 | 0.04 | ||
C/C | 66 | 0.96 | ||
Haplotype (rs8175347-rs4148323-rs34946978) | ||||
TA6GC | 0.76 | |||
TA6AC | 0.15 | |||
TA7GC | 0.065 | |||
TA6GT | 0.018 | |||
TA6AT | 0.0037 | |||