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Table 2 Demographic and laboratory characteristics of subjects with systemic viral infections alone (by emvPCR test); any systemic bacterial infection (SBI); or no systemic virus or bacterial infection. emvPCR experimental multiplexed viral PCR, WBC white blood cell count, LE leukocyte esterase, CSF cerebrospinal fluid, UTI urinary tract infection

From: A multicenter evaluation of viral bloodstream detections in children presenting to the Emergency Department with suspected systemic infection

  Systemic virus only (n = 214) Any SBI (n = 63) No systemic virus or SBI (n = 837) Odds Ratio (95% CI)a P-valuea
Age, mos, median (IQ range) 19 (7–56.5) 30 (9.5–86) 48 (17–111) 0.2629
< 0.0001
Sex, female, n (%) 91/214 (42.5%) 39/63 (61.9%) 389/837 (46.5%) 0.46 (0.25–0.82)
0.85 (0.63–1.16)
0.0094
0.3180
Season, fall/winter, n (%) 144/214 (67.3%) 39/63 (61.9%) 532/837 (63.6%) 1.27 (0.71–2.22)
1.18 (0.86–1.62)
0.451
0.3376
Hospitalized, n (%) 108/214 (50.5%) 52/63 (82.5%) 469/837 (53.0%) 0.22 (0.11–0.44)
0.80 (0.60–1.07)
< 0.0001
0.1658
WBC, median (IQ range) 10.3 (7.3–15.0) 10.9 (8.6–18.1) 9.6 (6.5–13.6) 0.5399
0.2347
Pyuria (+LE), n (%)b 11/207 (5.3%) 37/47 (78.7%) 56/366 (15.3%) 0.01 (0.01–0.04)
0.31 (0.16–0.59)
< 0.0001
0.0002
CSF WBC > 5/μL, n (%)c 7/16 (43.8%) 4/11 (36.4%) 19/45 (42.2%) 1.36 (0.28–5.44)
1.06 (0.35–3.62)
> 0.9999
> 0.9999
  1. aTop line compares “Systemic virus only” and “Any SBI” groups. Bottom line compares “Systemic virus only” and “No systemic virus or SBI” groups. For categorical variables, odds ratios and 95% confidence intervals were calculated using Fisher’s exact test. For continuous variables, P-values were calculated using one-way ANOVA with Tukey’s post-hoc multiple comparisons test
  2. bDenominator represents the number of subjects who had urinalyses with leukocyte esterase performed
  3. cDenominator represents the number of subjects who had CSF WBC performed