A multicenter evaluation of viral bloodstream detections in children presenting to the Emergency Department with suspected systemic infection

Table 2 Demographic and laboratory characteristics of subjects with systemic viral infections alone (by emvPCR test); any systemic bacterial infection (SBI); or no systemic virus or bacterial infection. emvPCR experimental multiplexed viral PCR, WBC white blood cell count, LE leukocyte esterase, CSF cerebrospinal fluid, UTI urinary tract infection

	Systemic virus only (n = 214)	Any SBI (n = 63)	No systemic virus or SBI (n = 837)	Odds Ratio (95% CI)^a	P-value^a
Age, mos, median (IQ range)	19 (7–56.5)	30 (9.5–86)	48 (17–111)	–	0.2629 < 0.0001
Sex, female, n (%)	91/214 (42.5%)	39/63 (61.9%)	389/837 (46.5%)	0.46 (0.25–0.82) 0.85 (0.63–1.16)	0.0094 0.3180
Season, fall/winter, n (%)	144/214 (67.3%)	39/63 (61.9%)	532/837 (63.6%)	1.27 (0.71–2.22) 1.18 (0.86–1.62)	0.451 0.3376
Hospitalized, n (%)	108/214 (50.5%)	52/63 (82.5%)	469/837 (53.0%)	0.22 (0.11–0.44) 0.80 (0.60–1.07)	< 0.0001 0.1658
WBC, median (IQ range)	10.3 (7.3–15.0)	10.9 (8.6–18.1)	9.6 (6.5–13.6)	–	0.5399 0.2347
Pyuria (+LE), n (%)^b	11/207 (5.3%)	37/47 (78.7%)	56/366 (15.3%)	0.01 (0.01–0.04) 0.31 (0.16–0.59)	< 0.0001 0.0002
CSF WBC > 5/μL, n (%)^c	7/16 (43.8%)	4/11 (36.4%)	19/45 (42.2%)	1.36 (0.28–5.44) 1.06 (0.35–3.62)	> 0.9999 > 0.9999

^aTop line compares “Systemic virus only” and “Any SBI” groups. Bottom line compares “Systemic virus only” and “No systemic virus or SBI” groups. For categorical variables, odds ratios and 95% confidence intervals were calculated using Fisher’s exact test. For continuous variables, P-values were calculated using one-way ANOVA with Tukey’s post-hoc multiple comparisons test
^bDenominator represents the number of subjects who had urinalyses with leukocyte esterase performed
^cDenominator represents the number of subjects who had CSF WBC performed

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