Quality of pediatric clinical practice guidelines

BMC Pediatrics

Table 3 Association of standardized scores in each domain by AGREE II and characteristics of guidelines using linear regression

Domain and subject	R²	Adjusted R²	β	95% CI	p
Scope and purpose	0.101	0.089
Constant			–	0.573, 0.620	< 0.001^**
Country/ Region			− 0.251	− 0.092, − 0.029	< 0.001^**
Organization/ Group			−0.096	− 0.077, 0.011	0.144
Evidence based			− 0.191	− 0.089, − 0.017	0.004^**
Stakeholder involvement	0.051	0.038
Constant			–	0.347, 0.406	< 0.001^**
Country/ Region			−0.136	−0.079, − 0.001	0.044^*
Organization/ Group			−0.002	−0.057, 0.055	0.972
Evidence based			−0.192	−0.110, − 0.020	0.005^**
Rigor of development	0.106	0.093
Constant			–	0.290, 0.360	< 0.001^**
Country/ Region			−0.034	−0.057, 0.033	0.608
Organization/ Group			−0.010	−0.069, 0.060	0.881
Evidence based			−0.325	−0.183, − 0.079	< 0.001^**
Clarity of presentation	0.141	0.129
Constant			–	0.666, 0.720	< 0.001^**
Country/ Region			0.061	−0.018, 0.052	0.341
Organization/ Group			−0.242	−0.146, − 0.046	< 0.001^**
Evidence based			−0.242	−0.118, − 0.037	< 0.001^**
Applicability	0.081	0.068
Constant			–	0.227, 0.283	< 0.001^**
Country/ Region			−0.156	−0.080, − 0.007	0.020^*
Organization/ Group			−0.167	−0.118, − 0.014	0.013^*
Evidence based			−0.172	−0.097, − 0.013	0.013^*
Editorial independence	0.031	0.017
Constant			–	0.345, 0.437	< 0.001^**
Country/ Region			−0.160	−0.131, − 0.012	0.019^*
Organization/ Group			0.034	−0.064, 0.107	0.618
Evidence based			−0.074	−0.107, 0.031	0.278
Overall assessment	0.142	0.130
Constant			–	4.386, 4.838	< 0.001^**
Country/ Region			−0.055	−0.425, 0.166	0.389
Organization/ Group			−0.179	−1.017, − 0.175	0.006^**
Evidence based			−0.312	−1.180, − 0.498	< 0.001^**

AGREE II The Appraisal of Guidelines for Research and Evaluation II; ^*p < 0.05 (linear regression); ^*p < 0.01 (linear regression)

ISSN: 1471-2431