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Table 3 Association of standardized scores in each domain by AGREE II and characteristics of guidelines using linear regression

From: Quality of pediatric clinical practice guidelines

Domain and subject R2 Adjusted R2 β 95% CI p
Scope and purpose 0.101 0.089    
 Constant    0.573, 0.620 < 0.001**
 Country/ Region    − 0.251 − 0.092, − 0.029 < 0.001**
 Organization/ Group    −0.096 − 0.077, 0.011 0.144
 Evidence based    − 0.191 − 0.089, − 0.017 0.004**
Stakeholder involvement 0.051 0.038    
 Constant    0.347, 0.406 < 0.001**
 Country/ Region    −0.136 −0.079, − 0.001 0.044*
 Organization/ Group    −0.002 −0.057, 0.055 0.972
 Evidence based    −0.192 −0.110, − 0.020 0.005**
Rigor of development 0.106 0.093    
 Constant    0.290, 0.360 < 0.001**
 Country/ Region    −0.034 −0.057, 0.033 0.608
 Organization/ Group    −0.010 −0.069, 0.060 0.881
 Evidence based    −0.325 −0.183, − 0.079 < 0.001**
Clarity of presentation 0.141 0.129    
 Constant    0.666, 0.720 < 0.001**
 Country/ Region    0.061 −0.018, 0.052 0.341
 Organization/ Group    −0.242 −0.146, − 0.046 < 0.001**
 Evidence based    −0.242 −0.118, − 0.037 < 0.001**
Applicability 0.081 0.068    
 Constant    0.227, 0.283 < 0.001**
 Country/ Region    −0.156 −0.080, − 0.007 0.020*
 Organization/ Group    −0.167 −0.118, − 0.014 0.013*
 Evidence based    −0.172 −0.097, − 0.013 0.013*
Editorial independence 0.031 0.017    
 Constant    0.345, 0.437 < 0.001**
 Country/ Region    −0.160 −0.131, − 0.012 0.019*
Organization/ Group    0.034 −0.064, 0.107 0.618
 Evidence based    −0.074 −0.107, 0.031 0.278
Overall assessment 0.142 0.130    
 Constant    4.386, 4.838 < 0.001**
 Country/ Region    −0.055 −0.425, 0.166 0.389
 Organization/ Group    −0.179 −1.017, − 0.175 0.006**
 Evidence based    −0.312 −1.180, − 0.498 < 0.001**
  1. AGREE II The Appraisal of Guidelines for Research and Evaluation II; *p < 0.05 (linear regression); *p < 0.01 (linear regression)