Neurocognitive function among HIV-infected children on protease inhibitor -based versus non-protease inhibitor based antiretroviral therapy in Uganda: a pilot study

Table 3 Mean differences in raw scores between children taking protease inhibitor and non-protease inhibitor-based antiretroviral therapy

Outcome	Antiretroviral therapy regimen		Mean difference (95% CI)	Hommel’s method corrected P value
Outcome	Non-PI based (n = 42)	PI based (n = 34)	Mean difference (95% CI)	Hommel’s method corrected P value
BOT, mean ± SE
Total BOT score	40.51 (1.24)	46.07 (1.40)	−5.56 (−9.66, − 1.45)	0.03
Motor control score	15.54 (0.61)	18.60 (0.70)	−3.07 (−5.11, − 1.03)	0.016
Manual coordination	11.57 (0.47)	12.65 (0.54)	−1.07 (−2.64, 0.49)	0.35
Body coordination	8.00 (0.23)	9.27 (0.27)	−1.27 (−2.05, − 0.49)	0.01
Strength and agility	5.41 (0.26)	5.55 (0.30)	−0.14 (−1.02, 0.74)	0.75

Abbreviations: PI Protease Inhibitor, SE Standard error.
All analyses were adjusted for WHO stage at ART initiation, cotrimoxazole prophylaxis, child born before term, socioeconomic status, child’s age, and MUAC. P values are adjusted for multiple testing using the Hommel’s method

ISSN: 1471-2431