Variable | MRD-ESKAPEEC n = 124 | Non-MRD ESKAPEEC n = 44 | Univariate analysis | Logistic Regression Analysis# | |
---|---|---|---|---|---|
P Value | P Value | Odds Ratio (95% CI) | |||
Male, No. (%) | 50 (40.3) | 18 (40.9) | 0.946 | Â | Â |
Age (m), Median (IQR) | 2.5 (0.5–26.4) | 9.7 (1.0–72.0) | 0.07 |  |  |
Presence of any underlying disease, No. (%) | 90 (72.6) | 19 (43.2) | < 0.001 | 0.469 | 1.376 (0.581–3.26) |
Premature and/or low birth weight, No. (%) | 44 (35.5) | 10 (22.7) | 0.120 | Â | Â |
Tumor diseases, No. (%) | 24 (19.4) | 5 (11.4) | 0.228 | Â | Â |
Aplastic anemia, No. (%) | 3 (2.4) | 0 | 0.568 | Â | Â |
Congenital heart disease, No. (%) | 10 (8.1) | 1 (2.3) | 0.327 | Â | Â |
Lung disease, No. (%) | 11 (8.9) | 1 (2.3) | 0.263 | Â | Â |
Digestive disease, No. (%) | 14 (11.3) | 1 (2.3) | 0.135 | Â | Â |
Kidney disease, No. (%) | 3 (2.4) | 1 (2.3) | 1.000 | Â | Â |
Other diseases, No. (%) | 7 (5.6) | 3 (6.8) | 1.000 | Â | Â |
Nosocomial infection, No. (%) | 51 (41.1) | 5 (11.4) | < 0.001 | 0.037 | 3.314 (1.076–10.205) |
Previous surgery and/ or trauma (within 3 months), No. (%) | 20 (16.1) | 4 (9.1) | 0.252 |  |  |
Previous hospitalization (within1 month), No. (%) | 27 (21.8) | 6 (13.6) | 0.243 | Â | Â |
Previous antibiotic use (within 1 month), No. (%) | 27 (21.8) | 19 (43.2) | 0.006 | 0.219 | 0.6 (0.266–1.356) |
Likely source of infections | |||||
 Lung infection, No. (%) | 27 (21.8) | 4 (9.1) | 0.062 |  |  |
 Abdominal infection, No. (%) | 20 (16.1) | 7 (15.9) | 0.973 |  |  |
 Urinary infection, No. (%) | 17 (13.7) | 9 (20.5) | 0.288 |  |  |
 Intracranial infection, No. (%) | 2 (1.6) | 0 | 1.000 |  |  |
 Skin or soft tissue infection, No. (%) | 8 (6.5) | 12 (27.3) | < 0.001 | 0.011 | 0.245 (0.083–0.721) |
 Primary BSI, No. (%) | 55 (44.4) | 14 (31.8) | 0.146 |  |  |
Laboratory findings | |||||
 White blood cell count (*10^9),Median (IQR) | 9.4 (4.9–13.9) | 9.8 (7.0–13.3) | 0.358 |  |  |
 Neutrophil percentage, Median (IQR) | 54.0 (33.4–71.0) | 58.8 (41.0–76.9) | 0.082 |  |  |
 Hemoglobin (g/L), Median (IQR) | 110.0 (91.8–150.0) | 104.5 (94.0–126.0) | 0.424 |  |  |
 Platelet count ((*10^9), Median (IQR) | 188 (100–302) | 271 (173–413) | 0.004 | 0.076 | 0.998 (0.996–1.000) |
 C-reactive protein (mg/dL), Median (IQR) | 9.5 (3.0–65.8) | 32.5 (2.3–150.7) | 0.203 |  |  |
 Elevated ALT, No. (%) | 39 (31.5) | 13 (29.5) | 0.814 |  |  |
 Elevated AST, No. (%) | 68 (54.8) | 18 (40.9) | 0.112 |  |  |
Severity of BSI | |||||
 MODS, No. (%) | 12 (9.7) | 1 (2.3) | 0.211 |  |  |
 Septic shock, No. (%) | 10 (8.1) | 0 | 0.065 |  |  |
 Mechanical ventilation, No. (%) | 32 (25.8) | 10 (22.7) | 0.685 |  |  |
 PICU admission, No. (%) | 18 (14.5) | 11 (25.0) | 0.114 |  |  |
 Length of hospital stay (days), Median (IQR) | 24.0 (13.0–36.0) | 14.5 (9.0–27.3) | 0.006 |  |  |
 7-day mortality | 8 (6.5) | 3 (6.8) | 1.000 |  |  |
 Overall mortality | 17 (13.7) | 5 (11.4) | 0.692 |  |  |
 Inappropriate empirical treatment, No. (%) | 42 (33.9) | 4 (9.1) | 0.002 |  |  |