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Table 4 Characteristics of interventional trials by funding sites, 2008–2019

From: Updated analysis of pediatric clinical studies registered in ClinicalTrials.gov, 2008–2019

 

Trials, No.(%)

χ2

P value

Single-site

(n = 22,176)

Multisite

(n = 9,726)

Enrollment

  

672.5

<  0.001a

 1–100

13,709(63.6)

4,606(48.0)

  

 101–1,000

6,554(30.4)

4,153(43.2)

  

 >1,000

1,282(6.0)

842(8.8)

  

Primary purpose_Treatment

  

482.9

<  0.001

 yes

12,152(54.8)

6,609(68.0)

  

 no

10,024(45.2)

3,117(32.0)

  

Intervention_Drug

  

1,276.9

<  0.001

 yes

6,933(31.3)

5,089(52.3)

  

 no

15,243(68.7)

4,637(47.7)

  
  1. χ2 test for effect of funding sites (Single-site, Multisite) influencing proportion of trials
  2. aMultiple comparisons: 101–1,000 vs > 1,000 adjusted p value = 0.480, p <  0.001 for those not specifically noted (adjustment method: fdr)